Matches in SemOpenAlex for { <https://semopenalex.org/work/W2789930908> ?p ?o ?g. }
- W2789930908 endingPage "680" @default.
- W2789930908 startingPage "671" @default.
- W2789930908 abstract "Preeclampsia is a common pregnancy-specific disorder characterized by elevated blood pressure and proteinuria. Activation of the maternal immune system and impaired placental angiogenesis are thought to contribute to the pathogenesis of preeclampsia. TLR9 (Toll-like receptor 9) plays a role in innate immunity, defending the organism against infection. The purpose of this study was to determine whether TLR9 inhibits angiogenesis at the fetomaternal interface under conditions of preeclampsia. We confirmed the downregulation of VEGFA (vascular endothelial growth factor A) and upregulation of TLR9 and sFLT1 (soluble vascular endothelial growth factor receptor 1) in placentas from preeclamptic women. Then, we established a mouse model with preeclampsia-like symptoms using the synthetic TLR9 agonist CpG (cytidine–phosphate–guanosine)-ODN (oligodeoxynucleotide; ODN1826). We observed the downregulation of VEGFA and the upregulation of sFLT1 in placentas from the preeclampsia-like animal model and in trophoblasts treated with CpG-ODN (ODN2006). In addition, silencing TLR9 promoted the migration and invasion of HTR8/SVneo cells. In conclusion, TLR9 is capable of robustly suppressing angiogenesis by differentially regulating the expression of VEGFA and sFLT1 at the fetomaternal interface, potentially contributing to the development of preeclampsia." @default.
- W2789930908 created "2018-03-29" @default.
- W2789930908 creator A5002338638 @default.
- W2789930908 creator A5013843249 @default.
- W2789930908 creator A5016880843 @default.
- W2789930908 creator A5019339756 @default.
- W2789930908 creator A5020129476 @default.
- W2789930908 creator A5025275630 @default.
- W2789930908 creator A5035850513 @default.
- W2789930908 creator A5047095469 @default.
- W2789930908 creator A5061801664 @default.
- W2789930908 creator A5064487127 @default.
- W2789930908 date "2018-04-01" @default.
- W2789930908 modified "2023-10-15" @default.
- W2789930908 title "TLR9 (Toll-Like Receptor 9) Agonist Suppresses Angiogenesis by Differentially Regulating VEGFA (Vascular Endothelial Growth Factor A) and sFLT1 (Soluble Vascular Endothelial Growth Factor Receptor 1) in Preeclampsia" @default.
- W2789930908 cites W1211039626 @default.
- W2789930908 cites W1789445397 @default.
- W2789930908 cites W1895687559 @default.
- W2789930908 cites W1899873857 @default.
- W2789930908 cites W1968609326 @default.
- W2789930908 cites W1982573088 @default.
- W2789930908 cites W1985781493 @default.
- W2789930908 cites W1986316483 @default.
- W2789930908 cites W1986652952 @default.
- W2789930908 cites W1992112921 @default.
- W2789930908 cites W1993474041 @default.
- W2789930908 cites W1996191588 @default.
- W2789930908 cites W1999389872 @default.
- W2789930908 cites W1999587028 @default.
- W2789930908 cites W2036469757 @default.
- W2789930908 cites W2046992587 @default.
- W2789930908 cites W2048226809 @default.
- W2789930908 cites W2051563676 @default.
- W2789930908 cites W2052417487 @default.
- W2789930908 cites W2053175799 @default.
- W2789930908 cites W2054456077 @default.
- W2789930908 cites W2060063306 @default.
- W2789930908 cites W2060071010 @default.
- W2789930908 cites W2064271377 @default.
- W2789930908 cites W2067532738 @default.
- W2789930908 cites W2073786825 @default.
- W2789930908 cites W2080815766 @default.
- W2789930908 cites W2091003012 @default.
- W2789930908 cites W2094746130 @default.
- W2789930908 cites W2098005560 @default.
- W2789930908 cites W2105744234 @default.
- W2789930908 cites W2107315506 @default.
- W2789930908 cites W2118011548 @default.
- W2789930908 cites W2129206669 @default.
- W2789930908 cites W2131275094 @default.
- W2789930908 cites W2133849259 @default.
- W2789930908 cites W2134502189 @default.
- W2789930908 cites W2134906341 @default.
- W2789930908 cites W2140724157 @default.
- W2789930908 cites W2149890706 @default.
- W2789930908 cites W2157381327 @default.
- W2789930908 cites W2159882259 @default.
- W2789930908 cites W2171841540 @default.
- W2789930908 cites W2289830263 @default.
- W2789930908 cites W2341980020 @default.
- W2789930908 cites W2430003272 @default.
- W2789930908 cites W2514044870 @default.
- W2789930908 cites W2583692897 @default.
- W2789930908 cites W4211203631 @default.
- W2789930908 doi "https://doi.org/10.1161/hypertensionaha.117.10510" @default.
- W2789930908 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29437897" @default.
- W2789930908 hasPublicationYear "2018" @default.
- W2789930908 type Work @default.
- W2789930908 sameAs 2789930908 @default.
- W2789930908 citedByCount "36" @default.
- W2789930908 countsByYear W27899309082018 @default.
- W2789930908 countsByYear W27899309082019 @default.
- W2789930908 countsByYear W27899309082020 @default.
- W2789930908 countsByYear W27899309082021 @default.
- W2789930908 countsByYear W27899309082022 @default.
- W2789930908 countsByYear W27899309082023 @default.
- W2789930908 crossrefType "journal-article" @default.
- W2789930908 hasAuthorship W2789930908A5002338638 @default.
- W2789930908 hasAuthorship W2789930908A5013843249 @default.
- W2789930908 hasAuthorship W2789930908A5016880843 @default.
- W2789930908 hasAuthorship W2789930908A5019339756 @default.
- W2789930908 hasAuthorship W2789930908A5020129476 @default.
- W2789930908 hasAuthorship W2789930908A5025275630 @default.
- W2789930908 hasAuthorship W2789930908A5035850513 @default.
- W2789930908 hasAuthorship W2789930908A5047095469 @default.
- W2789930908 hasAuthorship W2789930908A5061801664 @default.
- W2789930908 hasAuthorship W2789930908A5064487127 @default.
- W2789930908 hasBestOaLocation W27899309081 @default.
- W2789930908 hasConcept C104317684 @default.
- W2789930908 hasConcept C126322002 @default.
- W2789930908 hasConcept C127561419 @default.
- W2789930908 hasConcept C134018914 @default.
- W2789930908 hasConcept C140800825 @default.
- W2789930908 hasConcept C146285616 @default.
- W2789930908 hasConcept C14858245 @default.
- W2789930908 hasConcept C150194340 @default.
- W2789930908 hasConcept C15215337 @default.
- W2789930908 hasConcept C167734588 @default.