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- W2789932335 abstract "Increasing evidence shows that diabetes causes cardiac dysfunction. We hypothesized that a glucagon-like peptide-1 (GLP-1) analog, liraglutide, would attenuate cardiac dysfunction in diabetic rats. A total of 24 Sprague–Dawley (SD) rats were divided into two groups fed either a normal diet (normal, n=6) or a high-fat diet (HFD, n=18) for 4 weeks. Then, the HFD rats were injected with streptozotocin (STZ) to create a diabetic rat model. Diabetic rats were divided into three subgroups receiving vehicle (diabetic, n=6), a low dose of liraglutide (Llirag, 0.2 mg/kg/day, n=6), or a high dose of liraglutide (Hlirag, 0.4 mg/kg/day, n=6). Metabolic parameters, systolic blood pressure (SBP), heart rate (HR), left ventricular (LV) function, and whole genome expression of the heart were determined. Diabetic rats developed insulin resistance, increased blood lipid levels and oxidative stress, and impaired LV function, serum adiponectin, nitric oxide (NO). Liraglutide improved insulin resistance, serum adiponectin, NO, HR, and LV function and reduced blood triglyceride (TG), total cholesterol (TC) levels, and oxidative stress. Moreover, liraglutide increased heart nuclear receptor subfamily 1, group H, member 3 (Nr1h3), peroxisome proliferator activated receptor (Ppar) α (Pparα), and Srebp expression and reduced diacylglycerol O-acyltransferase 1 (Dgat) and angiopoietin-like 3 (Angptl3) expression. Liraglutide prevented cardiac dysfunction by activating the PPARα pathway to inhibit Dgat expression and oxidative stress in diabetic rats." @default.
- W2789932335 created "2018-03-29" @default.
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- W2789932335 date "2018-03-16" @default.
- W2789932335 modified "2023-10-04" @default.
- W2789932335 title "Liraglutide protects cardiac function in diabetic rats through the PPARα pathway" @default.
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- W2789932335 cites W1957970362 @default.
- W2789932335 cites W1967400215 @default.
- W2789932335 cites W1968631573 @default.
- W2789932335 cites W1973442218 @default.
- W2789932335 cites W1981473523 @default.
- W2789932335 cites W1983798804 @default.
- W2789932335 cites W1986046837 @default.
- W2789932335 cites W1992564227 @default.
- W2789932335 cites W1993783493 @default.
- W2789932335 cites W1999391010 @default.
- W2789932335 cites W2000137086 @default.
- W2789932335 cites W2001512276 @default.
- W2789932335 cites W2005563324 @default.
- W2789932335 cites W2024851295 @default.
- W2789932335 cites W2027504703 @default.
- W2789932335 cites W2028292209 @default.
- W2789932335 cites W2030682074 @default.
- W2789932335 cites W2034339368 @default.
- W2789932335 cites W2041345281 @default.
- W2789932335 cites W2045923887 @default.
- W2789932335 cites W2049135972 @default.
- W2789932335 cites W2057684242 @default.
- W2789932335 cites W2061642140 @default.
- W2789932335 cites W2062475390 @default.
- W2789932335 cites W2065623326 @default.
- W2789932335 cites W2070098406 @default.
- W2789932335 cites W2070768644 @default.
- W2789932335 cites W2074481698 @default.
- W2789932335 cites W2079082256 @default.
- W2789932335 cites W2084655984 @default.
- W2789932335 cites W2092221399 @default.
- W2789932335 cites W2096173332 @default.
- W2789932335 cites W2097893773 @default.
- W2789932335 cites W2101284986 @default.
- W2789932335 cites W2101293019 @default.
- W2789932335 cites W2102916729 @default.
- W2789932335 cites W2106937178 @default.
- W2789932335 cites W2107545755 @default.
- W2789932335 cites W2109193694 @default.
- W2789932335 cites W2109939117 @default.
- W2789932335 cites W2112327151 @default.
- W2789932335 cites W2115509231 @default.
- W2789932335 cites W2116015900 @default.
- W2789932335 cites W2120377931 @default.
- W2789932335 cites W2122683221 @default.
- W2789932335 cites W2123041020 @default.
- W2789932335 cites W2128385806 @default.
- W2789932335 cites W2133617810 @default.
- W2789932335 cites W2136496513 @default.
- W2789932335 cites W2139327524 @default.
- W2789932335 cites W2139342607 @default.
- W2789932335 cites W2143580786 @default.
- W2789932335 cites W2143587288 @default.
- W2789932335 cites W2148063868 @default.
- W2789932335 cites W2148521985 @default.
- W2789932335 cites W2150256240 @default.
- W2789932335 cites W2154492793 @default.
- W2789932335 cites W2156718297 @default.
- W2789932335 cites W2159416035 @default.
- W2789932335 cites W2161986195 @default.
- W2789932335 cites W2163127729 @default.
- W2789932335 cites W2168261002 @default.
- W2789932335 cites W2171332415 @default.
- W2789932335 cites W2234444148 @default.
- W2789932335 cites W2334545336 @default.
- W2789932335 cites W2335788856 @default.
- W2789932335 cites W2345410714 @default.
- W2789932335 cites W2472613996 @default.
- W2789932335 cites W2604768034 @default.
- W2789932335 cites W2617605538 @default.
- W2789932335 cites W2618984243 @default.
- W2789932335 cites W2742824716 @default.
- W2789932335 cites W992406347 @default.
- W2789932335 doi "https://doi.org/10.1042/bsr20180059" @default.
- W2789932335 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5857913" @default.
- W2789932335 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29440457" @default.
- W2789932335 hasPublicationYear "2018" @default.
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