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- W2789945528 abstract "In the hepatitis B virus (HBV)-related hepatocellular carcinoma tumor microenvironment (TME), monocytes reportedly impede natural T cell functions via PD-L1/PD-1 signaling. However, it remains unclear if T cell receptor-redirected T cells (TCR T cells) are similarly inhibited. Hence, we developed a 3D intrahepatic TME microfluidic model to investigate the immunosuppressive potential of monocytes toward HBV-specific TCR T cells and the role of PD-L1/PD-1 signaling. Interestingly, in our 3D static microfluidic model, we observed that monocytes suppressed only retrovirally transduced (Tdx) TCR T cell cytotoxicity toward cancer cells via PD-L1/PD-1, while mRNA electroporated (EP) TCR T cell cytotoxicity was not affected by the presence of monocytes. Importantly, when co-cultured in 2D, both Tdx and EP TCR T cell cytotoxicity toward cancer cells were not suppressed by monocytes, suggesting our 3D model as a superior tool compared to standard 2D assays for predicting TCR T cell efficacy in a preclinical setting, which can thus be used to improve current immunotherapy strategies." @default.
- W2789945528 created "2018-03-29" @default.
- W2789945528 creator A5007338010 @default.
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- W2789945528 date "2018-03-06" @default.
- W2789945528 modified "2023-10-12" @default.
- W2789945528 title "Characterizing the Role of Monocytes in T Cell Cancer Immunotherapy Using a 3D Microfluidic Model" @default.
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- W2789945528 doi "https://doi.org/10.3389/fimmu.2018.00416" @default.
- W2789945528 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5845585" @default.
- W2789945528 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29559973" @default.
- W2789945528 hasPublicationYear "2018" @default.
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