FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2789952845> ?p ?o ?g. }

• W2789952845 endingPage "2369" @default.
• W2789952845 startingPage "2356" @default.
• W2789952845 abstract "Abstract FOXO transcription factors are regulators of cellular homeostasis and putative tumor suppressors, yet the role of FOXO in cancer progression remains to be determined. The data on FOXO function, particularly for epithelial cancers, are fragmentary and come from studies that focused on isolated aspects of cancer. To clarify the role of FOXO in epithelial cancer progression, we characterized the effects of inducible FOXO activation and loss in a mouse model of metastatic invasive lobular carcinoma. Strikingly, either activation or loss of FOXO function suppressed tumor growth and metastasis. We show that the multitude of cellular processes critically affected by FOXO function include proliferation, survival, redox homeostasis, and PI3K signaling, all of which must be carefully balanced for tumor cells to thrive. Significance: FOXO proteins are not solely tumor suppressors, but also support tumor growth and metastasis by regulating a multitude of cellular processes essential for tumorigenesis. Cancer Res; 78(9); 2356–69. ©2018 AACR." @default.
• W2789952845 created "2018-03-29" @default.
• W2789952845 creator A5025639296 @default.
• W2789952845 creator A5027333160 @default.
• W2789952845 creator A5030871402 @default.
• W2789952845 creator A5033711163 @default.
• W2789952845 creator A5044440416 @default.
• W2789952845 creator A5048738552 @default.
• W2789952845 creator A5051227603 @default.
• W2789952845 creator A5065625528 @default.
• W2789952845 creator A5069562168 @default.
• W2789952845 creator A5082755917 @default.
• W2789952845 creator A5088755907 @default.
• W2789952845 date "2018-04-30" @default.
• W2789952845 modified "2023-10-13" @default.
• W2789952845 title "FOXO Transcription Factors Both Suppress and Support Breast Cancer Progression" @default.
• W2789952845 cites W1820314031 @default.
• W2789952845 cites W1890766043 @default.
• W2789952845 cites W1964847767 @default.
• W2789952845 cites W1969544207 @default.
• W2789952845 cites W1977267072 @default.
• W2789952845 cites W1991476773 @default.
• W2789952845 cites W2004398438 @default.
• W2789952845 cites W2021864751 @default.
• W2789952845 cites W2024290860 @default.
• W2789952845 cites W2024933597 @default.
• W2789952845 cites W2032427485 @default.
• W2789952845 cites W2038444072 @default.
• W2789952845 cites W2045493291 @default.
• W2789952845 cites W2045907249 @default.
• W2789952845 cites W2057247058 @default.
• W2789952845 cites W2059380603 @default.
• W2789952845 cites W2082852887 @default.
• W2789952845 cites W2085513070 @default.
• W2789952845 cites W2090546918 @default.
• W2789952845 cites W2100628426 @default.
• W2789952845 cites W2101096891 @default.
• W2789952845 cites W2104683328 @default.
• W2789952845 cites W2108541764 @default.
• W2789952845 cites W2124261225 @default.
• W2789952845 cites W2124580184 @default.
• W2789952845 cites W2135904335 @default.
• W2789952845 cites W2138242494 @default.
• W2789952845 cites W2138941583 @default.
• W2789952845 cites W2148192361 @default.
• W2789952845 cites W2151420456 @default.
• W2789952845 cites W2154558136 @default.
• W2789952845 cites W2154853638 @default.
• W2789952845 cites W2155228605 @default.
• W2789952845 cites W2162143298 @default.
• W2789952845 cites W2167795228 @default.
• W2789952845 cites W2168451979 @default.
• W2789952845 cites W2171990088 @default.
• W2789952845 cites W2217264961 @default.
• W2789952845 cites W2325641180 @default.
• W2789952845 cites W2331547930 @default.
• W2789952845 cites W2558715006 @default.
• W2789952845 cites W2560034399 @default.
• W2789952845 cites W2765507458 @default.
• W2789952845 doi "https://doi.org/10.1158/0008-5472.can-17-2511" @default.
• W2789952845 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29440168" @default.
• W2789952845 hasPublicationYear "2018" @default.
• W2789952845 type Work @default.
• W2789952845 sameAs 2789952845 @default.
• W2789952845 citedByCount "59" @default.
• W2789952845 countsByYear W27899528452018 @default.
• W2789952845 countsByYear W27899528452019 @default.
• W2789952845 countsByYear W27899528452020 @default.
• W2789952845 countsByYear W27899528452021 @default.
• W2789952845 countsByYear W27899528452022 @default.
• W2789952845 countsByYear W27899528452023 @default.
• W2789952845 crossrefType "journal-article" @default.
• W2789952845 hasAuthorship W2789952845A5025639296 @default.
• W2789952845 hasAuthorship W2789952845A5027333160 @default.
• W2789952845 hasAuthorship W2789952845A5030871402 @default.
• W2789952845 hasAuthorship W2789952845A5033711163 @default.
• W2789952845 hasAuthorship W2789952845A5044440416 @default.
• W2789952845 hasAuthorship W2789952845A5048738552 @default.
• W2789952845 hasAuthorship W2789952845A5051227603 @default.
• W2789952845 hasAuthorship W2789952845A5065625528 @default.
• W2789952845 hasAuthorship W2789952845A5069562168 @default.
• W2789952845 hasAuthorship W2789952845A5082755917 @default.
• W2789952845 hasAuthorship W2789952845A5088755907 @default.
• W2789952845 hasBestOaLocation W27899528452 @default.
• W2789952845 hasConcept C104317684 @default.
• W2789952845 hasConcept C121608353 @default.
• W2789952845 hasConcept C179185449 @default.
• W2789952845 hasConcept C2779013556 @default.
• W2789952845 hasConcept C2779256057 @default.
• W2789952845 hasConcept C502942594 @default.
• W2789952845 hasConcept C530470458 @default.
• W2789952845 hasConcept C54355233 @default.
• W2789952845 hasConcept C555283112 @default.
• W2789952845 hasConcept C62478195 @default.
• W2789952845 hasConcept C86339819 @default.
• W2789952845 hasConcept C86554907 @default.
• W2789952845 hasConcept C86803240 @default.
• W2789952845 hasConcept C95444343 @default.

• next