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- W2789968341 abstract "Cell signaling has been recognized as a highly dynamic process. How to capture such dynamics with changes of chemical microenvironment at single cell resolution among cells population without interfering with adjacent cells has been still an immense challenge. Here, we proposed a precision guided microfluidic chemical perfusion strategy for investigating chemical-activated cell signaling via dynamic imaging with high temporal (∼12 ms), spatial resolutions and precision. Theory for the microfluidic operation was first established and validated by both numerical simulations and experiments. A computer-aided multi-channel pressure control system was constructed to automatically implement chemical perturbations with various microperfusion times, relaxation times and number of cycles. The width and the position of the chemical microflow could also be precisely controlled with high reliability and accuracy. Investigations of intracellular and intercellular calcium signaling were successfully demonstrated using the proposed method. These results revealed that the precision guided microfluidic chemical perfusion strategy provided a versatile means for cell signaling analysis, which is potentially meaningful in chemical biology, cell biology and pharmacology." @default.
- W2789968341 created "2018-03-29" @default.
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- W2789968341 date "2018-06-01" @default.
- W2789968341 modified "2023-10-14" @default.
- W2789968341 title "Precision guided microfluidic chemical perfusion strategy for cell dynamic imaging" @default.
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- W2789968341 doi "https://doi.org/10.1016/j.snb.2018.01.195" @default.
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