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• W2790003140 abstract "The massive number of ingredients in traditional Chinese medicines (TCMs) makes quality control very difficult. The concept of quality markers (Q-marker) was recently proposed to evaluate the quality of TCMs. Xuezhiling tablets (XZL) are widely used for the treatment of hyperlipidemia in China owing to its noticeable effectiveness and mild adverse effects, but there are no proper Q-markers for this Chinese patent medicine. The aim of the present study was to determine the Q-markers of XZL against hyperlipidemia through an integration of investigations on its lipid-lowering effect, metabolomics, content determination and pharmacokinetics. XZL was prepared in accordance with the method described in the Chinese pharmacopoeia (Ch.P.). Hyperlipidemia was induced in rats through the administration of a high-fat diet (HFD). The hypolipidemic effect of XZL was investigated through the detection of the blood levels of total glyceride (TG), total cholesterol (TC), and low density lipoprotein cholesterol (LDL-C). A metabolomics study was conducted to analyze the overall effects of XZL on the regulation of lipid metabolism. The main bioactive compounds of XZL were identified and determined in the XZL preparation and the medicated plasma of hyperlipidemic rats. XZL lowered the levels of TG, TC, and LDL-C through alterations of metabolic patterns. 2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-glucopyranoside (THSG), chrysophanol-1-O-β-glucopyranosyl-(1→3)-O-β-D-glucopyranosy1-(1→6)-O-β-D-glucopyranosyl-(1→6)-O-β-D-glucopyranoside (SHJ), cassiaside, rubrofusarin gentiobioside, aurantio-obtusin, chryso-obtusin, and obtusinfolin were identified and determined both in the preparation and the blood of hyperlipidemic rats. SHJ, obtusinfolin, THSG, rubrofusarin gentiobioside, and aurantio-obtusin, which are more abundant in the preparation, leading to greater exposure in vivo, were suitable Q-markers to guarantee the medicinal quality of XZL and ensure the clinical effectiveness on hyperlipidemia." @default.
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• W2790003140 date "2018-05-01" @default.
• W2790003140 modified "2023-10-15" @default.
• W2790003140 title "Determination of quality markers of Xuezhiling tablet for hyperlipidemia treatment" @default.
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• W2790003140 doi "https://doi.org/10.1016/j.phymed.2018.03.004" @default.
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