Matches in SemOpenAlex for { <https://semopenalex.org/work/W2790008889> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2790008889 endingPage "341" @default.
- W2790008889 startingPage "333" @default.
- W2790008889 abstract "Abstract Nanotechnology based drug delivery systems have been explored extensively in cancer therapy over the past decades. Among the vast number of different materials used in nanocarrier systems, natural biopolymers are most frequently used in the encapsulation of chemotherapeutic drugs. However, the low solubility of these agents within biological fluid has decreased their efficacy for inhibiting the growth of cancer cells. Herein, we have developed a new biodegradable and biocompatible drug delivery system based on Dextran. Specifically, we have prepared lipid-conjugated dextran through esterification process using stearic acid (SA) and cholesterol (Chol). In vitro toxicity studies of unloaded and rapamycin loaded nanocarriers with U87 MG cell line showed that unloaded nanocarriers were non-toxic, and the IC50 value of encapsulated rapamycin for different formulations was lower than that for free rapamycin after 24 and 48 h incubation. Also, flow cytometry analysis fully supported the time dependent uptake of the nanocarriers by the cells. These results show that the synthesized polymers can potentially be used as a self-assembled carrier for loading of hydrophobic chemotherapeutics with enhanced toxicity against tumoral cancer cells." @default.
- W2790008889 created "2018-03-29" @default.
- W2790008889 creator A5021522417 @default.
- W2790008889 creator A5023298372 @default.
- W2790008889 creator A5029136297 @default.
- W2790008889 creator A5061318788 @default.
- W2790008889 creator A5082661377 @default.
- W2790008889 date "2018-04-01" @default.
- W2790008889 modified "2023-10-03" @default.
- W2790008889 title "Self-assembled amphiphilic-dextran nanomicelles for delivery of rapamycin" @default.
- W2790008889 cites W1964172630 @default.
- W2790008889 cites W1966631624 @default.
- W2790008889 cites W1967383536 @default.
- W2790008889 cites W1970991791 @default.
- W2790008889 cites W1975842800 @default.
- W2790008889 cites W1979362389 @default.
- W2790008889 cites W1980207776 @default.
- W2790008889 cites W1985513703 @default.
- W2790008889 cites W1988651862 @default.
- W2790008889 cites W1989928553 @default.
- W2790008889 cites W2001286327 @default.
- W2790008889 cites W2001410876 @default.
- W2790008889 cites W2003631032 @default.
- W2790008889 cites W2003766168 @default.
- W2790008889 cites W2004349712 @default.
- W2790008889 cites W2010312818 @default.
- W2790008889 cites W2015541518 @default.
- W2790008889 cites W2018589982 @default.
- W2790008889 cites W2036370359 @default.
- W2790008889 cites W2038743380 @default.
- W2790008889 cites W2068921478 @default.
- W2790008889 cites W2076670186 @default.
- W2790008889 cites W2093004080 @default.
- W2790008889 cites W2098596345 @default.
- W2790008889 cites W2104189774 @default.
- W2790008889 cites W2124451059 @default.
- W2790008889 cites W2161037023 @default.
- W2790008889 cites W2764507256 @default.
- W2790008889 doi "https://doi.org/10.1016/j.jddst.2018.01.010" @default.
- W2790008889 hasPublicationYear "2018" @default.
- W2790008889 type Work @default.
- W2790008889 sameAs 2790008889 @default.
- W2790008889 citedByCount "20" @default.
- W2790008889 countsByYear W27900088892019 @default.
- W2790008889 countsByYear W27900088892020 @default.
- W2790008889 countsByYear W27900088892021 @default.
- W2790008889 countsByYear W27900088892022 @default.
- W2790008889 countsByYear W27900088892023 @default.
- W2790008889 crossrefType "journal-article" @default.
- W2790008889 hasAuthorship W2790008889A5021522417 @default.
- W2790008889 hasAuthorship W2790008889A5023298372 @default.
- W2790008889 hasAuthorship W2790008889A5029136297 @default.
- W2790008889 hasAuthorship W2790008889A5061318788 @default.
- W2790008889 hasAuthorship W2790008889A5082661377 @default.
- W2790008889 hasConcept C15920480 @default.
- W2790008889 hasConcept C159985019 @default.
- W2790008889 hasConcept C171250308 @default.
- W2790008889 hasConcept C178790620 @default.
- W2790008889 hasConcept C185592680 @default.
- W2790008889 hasConcept C192562407 @default.
- W2790008889 hasConcept C2777339698 @default.
- W2790008889 hasConcept C2779820397 @default.
- W2790008889 hasConcept C521977710 @default.
- W2790008889 hasConcept C67407626 @default.
- W2790008889 hasConceptScore W2790008889C15920480 @default.
- W2790008889 hasConceptScore W2790008889C159985019 @default.
- W2790008889 hasConceptScore W2790008889C171250308 @default.
- W2790008889 hasConceptScore W2790008889C178790620 @default.
- W2790008889 hasConceptScore W2790008889C185592680 @default.
- W2790008889 hasConceptScore W2790008889C192562407 @default.
- W2790008889 hasConceptScore W2790008889C2777339698 @default.
- W2790008889 hasConceptScore W2790008889C2779820397 @default.
- W2790008889 hasConceptScore W2790008889C521977710 @default.
- W2790008889 hasConceptScore W2790008889C67407626 @default.
- W2790008889 hasLocation W27900088891 @default.
- W2790008889 hasOpenAccess W2790008889 @default.
- W2790008889 hasPrimaryLocation W27900088891 @default.
- W2790008889 hasRelatedWork W2031962541 @default.
- W2790008889 hasRelatedWork W2053512859 @default.
- W2790008889 hasRelatedWork W2115059274 @default.
- W2790008889 hasRelatedWork W2152419113 @default.
- W2790008889 hasRelatedWork W2736890253 @default.
- W2790008889 hasRelatedWork W2899084033 @default.
- W2790008889 hasRelatedWork W3125643247 @default.
- W2790008889 hasRelatedWork W3186589526 @default.
- W2790008889 hasRelatedWork W4213124376 @default.
- W2790008889 hasRelatedWork W2486634905 @default.
- W2790008889 hasVolume "44" @default.
- W2790008889 isParatext "false" @default.
- W2790008889 isRetracted "false" @default.
- W2790008889 magId "2790008889" @default.
- W2790008889 workType "article" @default.