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- W2790018487 abstract "Phytochemicals are of great pharmaceutical and agricultural importance, but often exhibit low abundance in nature. Recent demonstrations of industrial-scale production of phytochemicals in yeast have shown that microbial production of these high-value chemicals is a promising alternative to sourcing these molecules from native plant hosts. However, a number of challenges remain in the broader application of this approach, including the limited knowledge of plant secondary metabolism and the inefficient reconstitution of plant metabolic pathways in microbial hosts. In this Review, we discuss recent strategies to achieve microbial biosynthesis of complex phytochemicals, including strategies to: (1) reconstruct plant biosynthetic pathways that have not been fully elucidated by mining enzymes from native and non-native hosts or by enzyme engineering; (2) enhance plant enzyme activity, specifically cytochrome P450 activity, by improving efficiency, selectivity, expression or electron transfer; and (3) enhance overall reaction efficiency of multi-enzyme pathways by dynamic control, compartmentalization or optimization with the host’s metabolism. We also highlight remaining challenges to — and future opportunities of — this approach. Phytochemicals exhibit great pharmaceutical importance despite their low abundance in nature. The microbial biosynthesis of complex phytochemicals offers one route to increase their availability and production. This Review discusses recent strategies to reconstruct plant biosynthetic pathways that have not been fully elucidated; enhance plant enzyme activity; and enhance overall reaction efficiency of multi-enzyme pathways." @default.
- W2790018487 created "2018-03-29" @default.
- W2790018487 creator A5043892655 @default.
- W2790018487 creator A5048408108 @default.
- W2790018487 creator A5053196671 @default.
- W2790018487 date "2018-03-22" @default.
- W2790018487 modified "2023-10-02" @default.
- W2790018487 title "Strategies for microbial synthesis of high-value phytochemicals" @default.
- W2790018487 cites W1266593300 @default.
- W2790018487 cites W1487878063 @default.
- W2790018487 cites W1540714253 @default.
- W2790018487 cites W1567318028 @default.
- W2790018487 cites W1754687940 @default.
- W2790018487 cites W1781878639 @default.
- W2790018487 cites W1787875571 @default.
- W2790018487 cites W1872109272 @default.
- W2790018487 cites W1874287518 @default.
- W2790018487 cites W1977550796 @default.
- W2790018487 cites W1978806418 @default.
- W2790018487 cites W1990226486 @default.
- W2790018487 cites W1990812533 @default.
- W2790018487 cites W1998240064 @default.
- W2790018487 cites W2003117374 @default.
- W2790018487 cites W2006137883 @default.
- W2790018487 cites W2011945340 @default.
- W2790018487 cites W2014133014 @default.
- W2790018487 cites W2014177423 @default.
- W2790018487 cites W2023075963 @default.
- W2790018487 cites W2030168212 @default.
- W2790018487 cites W2034587087 @default.
- W2790018487 cites W2035014492 @default.
- W2790018487 cites W2036428713 @default.
- W2790018487 cites W2049207521 @default.
- W2790018487 cites W2050225360 @default.
- W2790018487 cites W2054980148 @default.
- W2790018487 cites W2057256243 @default.
- W2790018487 cites W2057351000 @default.
- W2790018487 cites W2067279194 @default.
- W2790018487 cites W2069573525 @default.
- W2790018487 cites W2072222282 @default.
- W2790018487 cites W2078159738 @default.
- W2790018487 cites W2090770676 @default.
- W2790018487 cites W2091282042 @default.
- W2790018487 cites W2092122738 @default.
- W2790018487 cites W2104031323 @default.
- W2790018487 cites W2104961996 @default.
- W2790018487 cites W2111973517 @default.
- W2790018487 cites W2119866908 @default.
- W2790018487 cites W2132444568 @default.
- W2790018487 cites W2136617468 @default.
- W2790018487 cites W2140464539 @default.
- W2790018487 cites W2140613686 @default.
- W2790018487 cites W2148161442 @default.
- W2790018487 cites W2148849061 @default.
- W2790018487 cites W2149202606 @default.
- W2790018487 cites W2154797402 @default.
- W2790018487 cites W2159628188 @default.
- W2790018487 cites W2163959508 @default.
- W2790018487 cites W2166323054 @default.
- W2790018487 cites W2168059482 @default.
- W2790018487 cites W2190591623 @default.
- W2790018487 cites W2195045928 @default.
- W2790018487 cites W2205790204 @default.
- W2790018487 cites W2268117688 @default.
- W2790018487 cites W2287869081 @default.
- W2790018487 cites W2294225971 @default.
- W2790018487 cites W2304674135 @default.
- W2790018487 cites W2322671676 @default.
- W2790018487 cites W2338387742 @default.
- W2790018487 cites W2404509431 @default.
- W2790018487 cites W2469380440 @default.
- W2790018487 cites W2470181883 @default.
- W2790018487 cites W2487997568 @default.
- W2790018487 cites W2507756519 @default.
- W2790018487 cites W2522890841 @default.
- W2790018487 cites W2541859010 @default.
- W2790018487 cites W255164579 @default.
- W2790018487 cites W2555171617 @default.
- W2790018487 cites W2596907809 @default.
- W2790018487 cites W2602443505 @default.
- W2790018487 cites W2607040243 @default.
- W2790018487 cites W2619839312 @default.
- W2790018487 cites W2625705805 @default.
- W2790018487 cites W4230243099 @default.
- W2790018487 cites W4230392683 @default.
- W2790018487 cites W796291325 @default.
- W2790018487 doi "https://doi.org/10.1038/s41557-018-0013-z" @default.
- W2790018487 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29568052" @default.
- W2790018487 hasPublicationYear "2018" @default.
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