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- W2790018833 abstract "SUMOylation is a reversible post-translational modification which has emerged as a crucial molecular regulatory mechanism, involved in the regulation of DNA damage repair, immune responses, carcinogenesis, cell cycle progression and apoptosis. Four SUMO isoforms have been identified, which are SUMO1, SUMO2/3 and SUMO4. The small ubiquitin-like modifier (SUMO) pathway is conserved in all eukaryotes and plays pivotal roles in the regulation of gene expression, cellular signaling and the maintenance of genomic integrity. The SUMO catalytic cycle includes maturation, activation, conjugation, ligation and de-modification. The dysregulation of the SUMO system is associated with a number of diseases, particularly cancer. SUMOylation is widely involved in carcinogenesis, DNA damage response, cancer cell proliferation, metastasis and apoptosis. SUMO can be used as a potential therapeutic target for cancer. In this review, we briefly outline the basic concepts of the SUMO system and summarize the involvement of SUMO proteins in cancer cells in order to better understand the role of SUMO in human disease." @default.
- W2790018833 created "2018-03-29" @default.
- W2790018833 creator A5017617819 @default.
- W2790018833 creator A5029331496 @default.
- W2790018833 creator A5029693068 @default.
- W2790018833 creator A5032683497 @default.
- W2790018833 creator A5035497448 @default.
- W2790018833 date "2018-02-22" @default.
- W2790018833 modified "2023-10-14" @default.
- W2790018833 title "The post-translational modification, SUMOylation, and cancer (Review)" @default.
- W2790018833 cites W1482992061 @default.
- W2790018833 cites W1513724442 @default.
- W2790018833 cites W1517778647 @default.
- W2790018833 cites W1530314158 @default.
- W2790018833 cites W1534596053 @default.
- W2790018833 cites W1539721085 @default.
- W2790018833 cites W1588994746 @default.
- W2790018833 cites W1664877711 @default.
- W2790018833 cites W1670550591 @default.
- W2790018833 cites W1799534295 @default.
- W2790018833 cites W1866623334 @default.
- W2790018833 cites W1892720553 @default.
- W2790018833 cites W1897794632 @default.
- W2790018833 cites W1918633965 @default.
- W2790018833 cites W1923637409 @default.
- W2790018833 cites W1933750453 @default.
- W2790018833 cites W1939670014 @default.
- W2790018833 cites W1963563716 @default.
- W2790018833 cites W1964675354 @default.
- W2790018833 cites W1964847767 @default.
- W2790018833 cites W1965073686 @default.
- W2790018833 cites W1967707683 @default.
- W2790018833 cites W1968354159 @default.
- W2790018833 cites W1969165489 @default.
- W2790018833 cites W1971358793 @default.
- W2790018833 cites W1973480232 @default.
- W2790018833 cites W1974875206 @default.
- W2790018833 cites W1976873804 @default.
- W2790018833 cites W1977491708 @default.
- W2790018833 cites W1978783141 @default.
- W2790018833 cites W1979666591 @default.
- W2790018833 cites W1980492996 @default.
- W2790018833 cites W1981243923 @default.
- W2790018833 cites W1981724027 @default.
- W2790018833 cites W1982343022 @default.
- W2790018833 cites W1982416172 @default.
- W2790018833 cites W1985617800 @default.
- W2790018833 cites W1987211450 @default.
- W2790018833 cites W1987344383 @default.
- W2790018833 cites W1987480357 @default.
- W2790018833 cites W1989643386 @default.
- W2790018833 cites W1993287528 @default.
- W2790018833 cites W1994473965 @default.
- W2790018833 cites W1995130497 @default.
- W2790018833 cites W1996611653 @default.
- W2790018833 cites W1996760634 @default.
- W2790018833 cites W1998123095 @default.
- W2790018833 cites W1999930997 @default.
- W2790018833 cites W2000129411 @default.
- W2790018833 cites W2000269915 @default.
- W2790018833 cites W2000647043 @default.
- W2790018833 cites W2001029086 @default.
- W2790018833 cites W2004641572 @default.
- W2790018833 cites W2004722555 @default.
- W2790018833 cites W2005178330 @default.
- W2790018833 cites W2006285635 @default.
- W2790018833 cites W2007054651 @default.
- W2790018833 cites W2007273883 @default.
- W2790018833 cites W2007336920 @default.
- W2790018833 cites W2008260297 @default.
- W2790018833 cites W2009128158 @default.
- W2790018833 cites W2009826707 @default.
- W2790018833 cites W2009931781 @default.
- W2790018833 cites W2010576862 @default.
- W2790018833 cites W2010897615 @default.
- W2790018833 cites W2013033866 @default.
- W2790018833 cites W2015004186 @default.
- W2790018833 cites W2016233579 @default.
- W2790018833 cites W2016581702 @default.
- W2790018833 cites W2017009483 @default.
- W2790018833 cites W2019139707 @default.
- W2790018833 cites W2021044341 @default.
- W2790018833 cites W2021176126 @default.
- W2790018833 cites W2021992655 @default.
- W2790018833 cites W2022469062 @default.
- W2790018833 cites W2022922908 @default.
- W2790018833 cites W2023114516 @default.
- W2790018833 cites W2027410891 @default.
- W2790018833 cites W2034728759 @default.
- W2790018833 cites W2036084208 @default.
- W2790018833 cites W2037215281 @default.
- W2790018833 cites W2037764420 @default.
- W2790018833 cites W2039575257 @default.
- W2790018833 cites W2041299849 @default.
- W2790018833 cites W2043503470 @default.
- W2790018833 cites W2045181724 @default.
- W2790018833 cites W2046677683 @default.
- W2790018833 cites W2046969377 @default.
- W2790018833 cites W2048370637 @default.
- W2790018833 cites W2048603115 @default.