Matches in SemOpenAlex for { <https://semopenalex.org/work/W2790036618> ?p ?o ?g. }
Showing items 1 to 61 of
61
with 100 items per page.
- W2790036618 endingPage "508a" @default.
- W2790036618 startingPage "508a" @default.
- W2790036618 abstract "Microtubules (MTs) are responsible for major cellular processes like cell motility, transport, and mitosis. Modulation of their structure and function in in vivo conditions is achieved by various microtubule associated proteins (MAPs). Among these MAPs are the MT severing enzymes, which belong to the ATP-dependent homo-hexamerases of ATPases associated with various cellular activities (AAA+) family of enzymes. These enzymes are known to bind to MTs in various orientations and for functional reasons they should bind to the acidic residue rich carboxy-terminal tails (CTTs) of tubulins. CTTs are known to be crucial for the severing of MTs, but the actual mechanism requiring CTTs is unknown. The current view is that severing proteins bind to CTTs and thread them through the center pore of the hexamer, thus facilitating severing. Using a combination of docking studies with molecular dynamics simulations and Normal Mode Analysis (NMA), we investigated the binding and dynamics of different CTT isoforms on severing proteins. We found that binding of Beta isoforms is preferred over Alpha isoforms, which recapitulates the behavior of katanin binding to CTTs from the experimental literature. Using the structural information resulting from docking for dynamic simulations can subsequently give insight into how the action of severing enzymes resembles that of AAA+ proteins in general, which involves the cooperative action of monomers or groups of monomers in a hexamer to perform the unfolding and translocation of substrates." @default.
- W2790036618 created "2018-03-29" @default.
- W2790036618 creator A5059499152 @default.
- W2790036618 date "2018-02-01" @default.
- W2790036618 modified "2023-10-18" @default.
- W2790036618 title "Disparate Roles of Alpha and Beta CTTs in Microtubule Severing" @default.
- W2790036618 doi "https://doi.org/10.1016/j.bpj.2017.11.2778" @default.
- W2790036618 hasPublicationYear "2018" @default.
- W2790036618 type Work @default.
- W2790036618 sameAs 2790036618 @default.
- W2790036618 citedByCount "0" @default.
- W2790036618 crossrefType "journal-article" @default.
- W2790036618 hasAuthorship W2790036618A5059499152 @default.
- W2790036618 hasBestOaLocation W27900366181 @default.
- W2790036618 hasConcept C104317684 @default.
- W2790036618 hasConcept C12554922 @default.
- W2790036618 hasConcept C159110408 @default.
- W2790036618 hasConcept C181199279 @default.
- W2790036618 hasConcept C185592680 @default.
- W2790036618 hasConcept C189754071 @default.
- W2790036618 hasConcept C20418707 @default.
- W2790036618 hasConcept C41685203 @default.
- W2790036618 hasConcept C53345823 @default.
- W2790036618 hasConcept C55493867 @default.
- W2790036618 hasConcept C71924100 @default.
- W2790036618 hasConcept C86803240 @default.
- W2790036618 hasConcept C95444343 @default.
- W2790036618 hasConceptScore W2790036618C104317684 @default.
- W2790036618 hasConceptScore W2790036618C12554922 @default.
- W2790036618 hasConceptScore W2790036618C159110408 @default.
- W2790036618 hasConceptScore W2790036618C181199279 @default.
- W2790036618 hasConceptScore W2790036618C185592680 @default.
- W2790036618 hasConceptScore W2790036618C189754071 @default.
- W2790036618 hasConceptScore W2790036618C20418707 @default.
- W2790036618 hasConceptScore W2790036618C41685203 @default.
- W2790036618 hasConceptScore W2790036618C53345823 @default.
- W2790036618 hasConceptScore W2790036618C55493867 @default.
- W2790036618 hasConceptScore W2790036618C71924100 @default.
- W2790036618 hasConceptScore W2790036618C86803240 @default.
- W2790036618 hasConceptScore W2790036618C95444343 @default.
- W2790036618 hasIssue "3" @default.
- W2790036618 hasLocation W27900366181 @default.
- W2790036618 hasOpenAccess W2790036618 @default.
- W2790036618 hasPrimaryLocation W27900366181 @default.
- W2790036618 hasRelatedWork W1970416288 @default.
- W2790036618 hasRelatedWork W2025398173 @default.
- W2790036618 hasRelatedWork W2026867892 @default.
- W2790036618 hasRelatedWork W2029035502 @default.
- W2790036618 hasRelatedWork W2066516984 @default.
- W2790036618 hasRelatedWork W2084112383 @default.
- W2790036618 hasRelatedWork W2122659522 @default.
- W2790036618 hasRelatedWork W2164249563 @default.
- W2790036618 hasRelatedWork W2183866633 @default.
- W2790036618 hasRelatedWork W2802433486 @default.
- W2790036618 hasVolume "114" @default.
- W2790036618 isParatext "false" @default.
- W2790036618 isRetracted "false" @default.
- W2790036618 magId "2790036618" @default.
- W2790036618 workType "article" @default.