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• W2790048211 abstract "Abstract Photoactivated DNA interstrand cross‐linking agents have a wide range of biological applications. Recently, several aryl boronates have been reported to induce DNA interstrand cross‐link (ICL) formation via carbocations upon photoirradiation. Herein, we synthesized a series of new bifunctional phenyl compounds to test the generality of such a mechanism, and to understand how the chemical structure influences carbocation formation and the DNA cross‐linking process. These compounds efficiently form DNA ICLs via generated benzyl cations upon 350 nm irradiation. The DNA cross‐linking efficiency and the pathway for carbocation generation depend on both the aromatic substituents and the leaving groups. Bromine as a leaving group facilitates the DNA cross‐linking process in comparison with trimethyl ammonium salt. Both electron‐donating and ‐withdrawing substituents induce bathochromic shifts, which favor photoinduced DNA ICL formation. For the bromides, the benzyl cation intermediates were generated through oxidation of the corresponding benzyl radicals. However, for the ammonia salts, the benzyl cations were formed through two pathways: either through oxidation of the benzyl radicals or by direct heterolysis of the C−N bond. Photoinduced C−N homolysis to form benzyl radicals occurred with compounds having donating substituents, whereas direct heterolysis of the C−N bond occurred with those bearing withdrawing substituents. The adducts formed between 1 a and four natural nucleosides were characterized, indicating that the alkylation sites for the photogenerated benzyl cations are dG, dA, and dC." @default.
• W2790048211 created "2018-03-29" @default.
• W2790048211 creator A5031617786 @default.
• W2790048211 creator A5041898064 @default.
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• W2790048211 date "2018-05-07" @default.
• W2790048211 modified "2023-10-14" @default.
• W2790048211 title "Substituents Have a Large Effect on Photochemical Generation of Benzyl Cations and DNA Cross-Linking" @default.
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• W2790048211 doi "https://doi.org/10.1002/chem.201705929" @default.
• W2790048211 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29479750" @default.
• W2790048211 hasPublicationYear "2018" @default.
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