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• W2790073516 abstract "Abstract This study aimed to investigate the efficacy of mangiferin, including its known antioxidant and anti‐inflammatory effects on sepsis‐induced lung injury induced by a classical cecal ligation and puncture (CLP) models in mouse using a metabolomics approach. A total of 24 mice were randomly divided into four groups: the sham group was given saline before sham operation. The CLP group received the CLP operation only. HMF and LMF groups were given mangiferin treatment of high dose and low dose of mangiferin, respectively, before the CLP operation. One week after treatment, the mice were sacrificed and their lungs were collected for metabolomics analysis. We developed ultra‐performance liquid chromatography coupled with quadrupole‐time‐of‐flight mass spectrometry to perform lung metabolic profiling analysis. With the methods of principal component analysis and partial least squares discriminant analysis, 58 potential metabolites associated with amino acid metabolism, purine metabolism, lipid metabolism and energy regulation were observed to be increased or reduced in HMF and LMF groups compared with the CLP group. Conclusively, our results suggest that mangiferin plays a protective role in the moderation of sepsis‐induced lung injury through reducing oxidative stress, regulating lipid metabolism and energy biosynthesis." @default.
• W2790073516 created "2018-03-29" @default.
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• W2790073516 date "2018-03-24" @default.
• W2790073516 modified "2023-09-27" @default.
• W2790073516 title "Metabolomic analysis for the protective effects of mangiferin on sepsis-induced lung injury in mice" @default.
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• W2790073516 doi "https://doi.org/10.1002/bmc.4208" @default.
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