Matches in SemOpenAlex for { <https://semopenalex.org/work/W2790080265> ?p ?o ?g. }
- W2790080265 abstract "The spectrum of clinical forms observed in leprosy and its pathogenesis are dictated by the host's immune response against Mycobacterium leprae, the etiological agent of leprosy. Previous results, based on metabolomics studies, demonstrated a strong relationship between clinical manifestations of leprosy and alterations in the metabolism of ω3 and ω6 polyunsaturated fatty acids (PUFAs), and the diverse set of lipid mediators derived from PUFAs. PUFA-derived lipid mediators provide multiple functions during acute inflammation, and some lipid mediators are able to induce both pro- and anti-inflammatory responses as determined by the cell surface receptors being expressed, as well as the cell type expressing the receptors. However, little is known about how these compounds influence cellular immune activities during chronic granulomatous infectious diseases, such as leprosy. Current evidence suggests that specialized pro-resolving lipid mediators (SPMs) are involved in the down-modulation of the innate and adaptive immune response against M. leprae and that alteration in the homeostasis of pro-inflammatory lipid mediators versus SPMs is associated with dramatic shifts in the pathogenesis of leprosy. In this review, we discuss the possible consequences and present new hypotheses for the involvement of ω3 and ω6 PUFA metabolism in the pathogenesis of leprosy. A specific emphasis is placed on developing models of lipid mediator interactions with the innate and adaptive immune responses and the influence of these interactions on the outcome of leprosy." @default.
- W2790080265 created "2018-03-29" @default.
- W2790080265 creator A5011534163 @default.
- W2790080265 creator A5048234944 @default.
- W2790080265 date "2018-02-02" @default.
- W2790080265 modified "2023-09-27" @default.
- W2790080265 title "Host Lipid Mediators in Leprosy: The Hypothesized Contributions to Pathogenesis" @default.
- W2790080265 cites W1498678348 @default.
- W2790080265 cites W1528348211 @default.
- W2790080265 cites W1528753621 @default.
- W2790080265 cites W1531140346 @default.
- W2790080265 cites W1544448943 @default.
- W2790080265 cites W1553386677 @default.
- W2790080265 cites W1555731614 @default.
- W2790080265 cites W155774906 @default.
- W2790080265 cites W1587539418 @default.
- W2790080265 cites W1640854798 @default.
- W2790080265 cites W1668867309 @default.
- W2790080265 cites W1832132481 @default.
- W2790080265 cites W1872869018 @default.
- W2790080265 cites W1889359478 @default.
- W2790080265 cites W1919972434 @default.
- W2790080265 cites W1967312698 @default.
- W2790080265 cites W1967975652 @default.
- W2790080265 cites W1968623565 @default.
- W2790080265 cites W1971595233 @default.
- W2790080265 cites W1973501241 @default.
- W2790080265 cites W1973632746 @default.
- W2790080265 cites W1973922785 @default.
- W2790080265 cites W1974055636 @default.
- W2790080265 cites W1974260134 @default.
- W2790080265 cites W1975370877 @default.
- W2790080265 cites W1976213001 @default.
- W2790080265 cites W1980360365 @default.
- W2790080265 cites W1983754832 @default.
- W2790080265 cites W1984331348 @default.
- W2790080265 cites W1986514504 @default.
- W2790080265 cites W1987492845 @default.
- W2790080265 cites W1989856248 @default.
- W2790080265 cites W1990767821 @default.
- W2790080265 cites W1991132011 @default.
- W2790080265 cites W1994616470 @default.
- W2790080265 cites W1997561160 @default.
- W2790080265 cites W1997621811 @default.
- W2790080265 cites W1997869572 @default.
- W2790080265 cites W2000545225 @default.
- W2790080265 cites W2000915512 @default.
- W2790080265 cites W2001104070 @default.
- W2790080265 cites W2003206211 @default.
- W2790080265 cites W2003708730 @default.
- W2790080265 cites W2004192317 @default.
- W2790080265 cites W2004361285 @default.
- W2790080265 cites W2005783937 @default.
- W2790080265 cites W2006332559 @default.
- W2790080265 cites W2015006881 @default.
- W2790080265 cites W2017106643 @default.
- W2790080265 cites W2018785836 @default.
- W2790080265 cites W2026311711 @default.
- W2790080265 cites W2030691041 @default.
- W2790080265 cites W2037231636 @default.
- W2790080265 cites W2038407955 @default.
- W2790080265 cites W2038974248 @default.
- W2790080265 cites W2044185186 @default.
- W2790080265 cites W2046684889 @default.
- W2790080265 cites W2049372707 @default.
- W2790080265 cites W2050875299 @default.
- W2790080265 cites W2051693683 @default.
- W2790080265 cites W2053444759 @default.
- W2790080265 cites W2057459612 @default.
- W2790080265 cites W2060066878 @default.
- W2790080265 cites W2062740146 @default.
- W2790080265 cites W2069147864 @default.
- W2790080265 cites W2070487932 @default.
- W2790080265 cites W2075582594 @default.
- W2790080265 cites W2075714705 @default.
- W2790080265 cites W2076136027 @default.
- W2790080265 cites W2077699493 @default.
- W2790080265 cites W2079771762 @default.
- W2790080265 cites W2079876525 @default.
- W2790080265 cites W2080998293 @default.
- W2790080265 cites W2084117223 @default.
- W2790080265 cites W2084624382 @default.
- W2790080265 cites W2089162053 @default.
- W2790080265 cites W2089857811 @default.
- W2790080265 cites W2091026399 @default.
- W2790080265 cites W2093294340 @default.
- W2790080265 cites W2093631337 @default.
- W2790080265 cites W2095397983 @default.
- W2790080265 cites W2097096084 @default.
- W2790080265 cites W2099967945 @default.
- W2790080265 cites W2100705331 @default.
- W2790080265 cites W2101829684 @default.
- W2790080265 cites W2102189561 @default.
- W2790080265 cites W2102897270 @default.
- W2790080265 cites W2103017931 @default.
- W2790080265 cites W2103045841 @default.
- W2790080265 cites W2104590073 @default.
- W2790080265 cites W2104627972 @default.
- W2790080265 cites W2105020714 @default.
- W2790080265 cites W2105622887 @default.