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- W2790088686 abstract "Common variable immunodeficiency (CVID) is the most frequent form of immunodeficiency in adults. Clinical manifestations are heterogeneous with an increased susceptibility to infections and inflammatory conditions, namely autoimmune diseases, such as inflammatory bowel disease. We present the clinical case of a Caucasian female patient, 21 years old, with a past medical history of CVID, with multiple visits to the emergency department due to abdominal pain in the lower quadrants and diarrhea. Her biochemical analysis showed elevated inflammatory parameters. Stool cultures and parasitological examination of feces were negative. Ileocolonoscopy revealed lymphoid nodular hyperplasia of the terminal ileum, and the small bowel capsule endoscopy demonstrated edema and multiple pleomorphic ulcers (Lewis score = 1,104). CVID-associated inflammatory enteropathy was suspected. Budesonide 9 mg/day was started, but no positive clinical response was observed. It was decided to initiate biological therapy with infliximab. The patient's condition is currently clinically improved with no complications due to biological therapy.A imunodeficiência variável comum (IDVC) é a forma mais frequente de imunodeficiência no adulto. O conjunto de manifestações clínicas é heterogéneo com uma susceti-bilidade aumentada a infeções e condições inflamatórias, nomeadamente autoimunes como a doença inflamatória intestinal. Apresenta-se um caso clínico de doente do. sexo feminino, 21 anos de idade com antecedentes de imunodeficiência variável comum, com múltiplas admis-sões ao serviço de urgência por dor abdominal nos quadrantes inferiores e diarreia. Analiticamente apresen-tava parâmetros inflamatórios elevados. As coproculturas e exame parasitológico de fezes eram negativos. A ileoco-lonoscopia revelou hiperplasia nodular linfóide do íleon terminal e a enteroscopia por cápsula edema marcado e múltiplas úlceras pleomórficas (Score de Lewis 1104). Sus-peitou-se de enteropatia inflamatória associada a IDVC. Iniciou Budesonido 9 mg/dia não tendo sido verificada resposta clínica positiva. Foi decidido iniciar terapêutica biológica com Infliximab. A doente encontra-se, atual-mente, clinicamente melhorada sem evidência de ativi-dade inflamatória." @default.
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- W2790088686 date "2018-01-01" @default.
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- W2790088686 title "Common Variable Immunodeficiency-Associated Inflammatory Enteropathy: The New Era of Biological Therapy" @default.
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- W2790088686 doi "https://doi.org/10.1159/000486448" @default.
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