FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2790099097> ?p ?o ?g. }

• W2790099097 abstract "Promoter status of O6-methylguanine-DNA methyltransferase (MGMT) has been widely established as a clinically relevant factor in glioblastoma (GBM) patients. However, in addition to varied therapy schedule, the prognosis of GBM patients is also affected by variations of age, race, primary or recurrent tumor. This study comprehensively investigated the association between MGMT promoter status and prognosis in overall GBM patients and in different GBM subtype including new diagnosed patients, recurrent patients and elderly patients.A comprehensive search was performed using PubMed, EMBASE, Cochrane databases to identify literatures (published from January 1, 2005 to April 1, 2017) that evaluated the associations between MGMT promoter methylation and prognosis of GBM patients.Totally, 66 studies including 7,886 patients met the inclusion criteria. Overall GBM patients with a methylated status of MGMT receiving temozolomide (TMZ)-containing treatment had better overall survival (OS) and progression-free survival (PFS) [OS: hazard ratio (HR) = 0.46, 95% confidence interval (CI): 0.41-0.52, p < 0.001, Bon = 0.017; PFS: HR = 0.48, 95% CI 0.40-0.57, p < 0.001, Bon = 0.014], but no significant advantage on OS or PFS in GBM patients with TMZ-free treatment was observed (OS: HR = 0.97, 95% CI 0.91-1.03, p = 0.08, Bon = 1; PFS: HR = 0.76, 95% CI 0.57-1.02, p = 0.068, Bon = 0.748). These different impacts of MGMT status on OS were similar in newly diagnosed GBM patients, elderly GBM patients and recurrent GBM. Among patients receiving TMZ-free treatment, survival benefit in Asian patients was not observed anymore after Bonferroni correction (Asian OS: HR = 0.78, 95% CI 0.64-0.95, p = 0.02, Bon = 0.24, I2 = 0%; PFS: HR = 0.69, 95% CI 0.50-0.94, p = 0.02, Bon = 0.24). No benefit was observed in Caucasian receiving TMZ-free therapy regardless of Bonferroni adjustment.The meta-analysis highlights the universal predictive value of MGMT methylation in newly diagnosed GBM patients, elderly GBM patients and recurrent GBM patients. For elderly methylated GBM patients, TMZ alone therapy might be a more suitable option than radiotherapy alone therapy. Future clinical trials should be designed in order to optimize therapeutics in different GBM subpopulation." @default.
• W2790099097 created "2018-03-29" @default.
• W2790099097 creator A5008863850 @default.
• W2790099097 creator A5009012652 @default.
• W2790099097 creator A5020215116 @default.
• W2790099097 creator A5051363890 @default.
• W2790099097 creator A5052391925 @default.
• W2790099097 creator A5058019217 @default.
• W2790099097 creator A5074461919 @default.
• W2790099097 creator A5074877012 @default.
• W2790099097 creator A5083952278 @default.
• W2790099097 creator A5086647411 @default.
• W2790099097 date "2018-03-21" @default.
• W2790099097 modified "2023-10-15" @default.
• W2790099097 title "The Clinical Significance of O6-Methylguanine-DNA Methyltransferase Promoter Methylation Status in Adult Patients With Glioblastoma: A Meta-analysis" @default.
• W2790099097 cites W1483849344 @default.
• W2790099097 cites W1503484563 @default.
• W2790099097 cites W1651982135 @default.
• W2790099097 cites W1772765560 @default.
• W2790099097 cites W1903052549 @default.
• W2790099097 cites W1918200890 @default.
• W2790099097 cites W1964435302 @default.
• W2790099097 cites W1982748425 @default.
• W2790099097 cites W1990795133 @default.
• W2790099097 cites W1994069902 @default.
• W2790099097 cites W2001902450 @default.
• W2790099097 cites W2002378112 @default.
• W2790099097 cites W2006288539 @default.
• W2790099097 cites W2006776134 @default.
• W2790099097 cites W2012909561 @default.
• W2790099097 cites W2016045856 @default.
• W2790099097 cites W2017251238 @default.
• W2790099097 cites W2019425272 @default.
• W2790099097 cites W2025634492 @default.
• W2790099097 cites W2029308958 @default.
• W2790099097 cites W2033585778 @default.
• W2790099097 cites W2035021866 @default.
• W2790099097 cites W2036044314 @default.
• W2790099097 cites W2042783322 @default.
• W2790099097 cites W2044792043 @default.
• W2790099097 cites W2045330322 @default.
• W2790099097 cites W2050269130 @default.
• W2790099097 cites W2050711634 @default.
• W2790099097 cites W2052491055 @default.
• W2790099097 cites W2059624809 @default.
• W2790099097 cites W2062522653 @default.
• W2790099097 cites W2076707297 @default.
• W2790099097 cites W2083788852 @default.
• W2790099097 cites W2088095316 @default.
• W2790099097 cites W2092758013 @default.
• W2790099097 cites W2102256364 @default.
• W2790099097 cites W2103987247 @default.
• W2790099097 cites W2107203636 @default.
• W2790099097 cites W2107328434 @default.
• W2790099097 cites W2107731988 @default.
• W2790099097 cites W2112014411 @default.
• W2790099097 cites W2112170577 @default.
• W2790099097 cites W2115597075 @default.
• W2790099097 cites W2115615891 @default.
• W2790099097 cites W2121625674 @default.
• W2790099097 cites W2124567314 @default.
• W2790099097 cites W2124815276 @default.
• W2790099097 cites W2126809148 @default.
• W2790099097 cites W2126930838 @default.
• W2790099097 cites W2129437923 @default.
• W2790099097 cites W2131981377 @default.
• W2790099097 cites W2132607958 @default.
• W2790099097 cites W2132984648 @default.
• W2790099097 cites W2133175627 @default.
• W2790099097 cites W2133367407 @default.
• W2790099097 cites W2133953251 @default.
• W2790099097 cites W2135396269 @default.
• W2790099097 cites W2135947790 @default.
• W2790099097 cites W2140746183 @default.
• W2790099097 cites W2141589246 @default.
• W2790099097 cites W2146904439 @default.
• W2790099097 cites W2149768128 @default.
• W2790099097 cites W2150000105 @default.
• W2790099097 cites W2151485047 @default.
• W2790099097 cites W2152158152 @default.
• W2790099097 cites W2152562611 @default.
• W2790099097 cites W2153558039 @default.
• W2790099097 cites W2154526619 @default.
• W2790099097 cites W2154898479 @default.
• W2790099097 cites W2155524619 @default.
• W2790099097 cites W2158681922 @default.
• W2790099097 cites W2160046825 @default.
• W2790099097 cites W2164481774 @default.
• W2790099097 cites W2164753697 @default.
• W2790099097 cites W2165544400 @default.
• W2790099097 cites W2165871546 @default.
• W2790099097 cites W2167713837 @default.
• W2790099097 cites W2167923186 @default.
• W2790099097 cites W2171714209 @default.
• W2790099097 cites W2187613252 @default.
• W2790099097 cites W2252317757 @default.
• W2790099097 cites W2256016639 @default.
• W2790099097 cites W2266544059 @default.
• W2790099097 cites W2267733139 @default.
• W2790099097 cites W2286503151 @default.

• next