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• W2790172423 endingPage "e22042" @default.
• W2790172423 startingPage "e22042" @default.
• W2790172423 abstract "During this investigation, N,N'-bis-azidomethylamines, N,N'-bis-cyanomethylamine, new alkoxymethylamine and chiral derivatives, which are considered to be a new generation of multifunctional compounds, were synthesized, functional properties were investigated, and anticholinergic and antidiabetic properties of those compounds were studied through the laboratory tests, and it was approved that they contain physiologically active compounds rather than analogues. Novel N-bis-cyanomethylamine and alkoxymethylamine derivatives were effective inhibitors of the α-glycosidase, cytosolic carbonic anhydrase I and II isoforms, butyrylcholinesterase (BChE), and acetylcholinesterase (AChE) with Ki values in the range of 0.15-13.31 nM for α-glycosidase, 2.77-15.30 nM for human carbonic anhydrase isoenzymes I (hCA I), 3.12-21.90 nM for human carbonic anhydrase isoenzymes II (hCA II), 23.33-73.23 nM for AChE, and 3.84-48.41 nM for BChE, respectively. Indeed, the inhibition of these metabolic enzymes has been considered as a promising factor for pharmacologic intervention in a diversity of disturbances." @default.
• W2790172423 created "2018-03-29" @default.
• W2790172423 creator A5035076116 @default.
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• W2790172423 creator A5054467099 @default.
• W2790172423 creator A5086389192 @default.
• W2790172423 date "2018-02-19" @default.
• W2790172423 modified "2023-09-26" @default.
• W2790172423 title "Synthesis and discovery of potent carbonic anhydrase, acetylcholinesterase, butyrylcholinesterase, and α-glycosidase enzymes inhibitors: The novel<i>N</i>,<i>N</i>′-bis-cyanomethylamine and alkoxymethylamine derivatives" @default.
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• W2790172423 doi "https://doi.org/10.1002/jbt.22042" @default.
• W2790172423 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29457667" @default.
• W2790172423 hasPublicationYear "2018" @default.
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