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• W2790174429 abstract "Vulvodynia is the most common type of chronic pelvic pain and dyspareunia in premenopausal women. The effect of drugs for the treatment of vulvodynia remains poorly discussed.To conduct a systematic review of randomised controlled studies which assess medications used to treat vulvar pain in vulvodynia.Web of Science, Cochrane Library, EBSCO Academic, LILACS and MEDLINE were searched from 1985 to September 2016.Randomised controlled trials comparing any kind of medication for vulvodynia treatment with placebo or with another medication in adult patients were included.The two investigators independently conducted data extraction. The synthesis was provided by the pain reduction index. Study quality assessment was performed using the Cochrane Handbook for Systematic Reviews of Intervention and analysis of publication bias was conducted.Five studies were included in qualitative synthesis. Number of participants varied from 30 to 133 participants among the eligible studies, resulting in a total of 297 patients. The pain reduction rates of patients with vulvodynia assessed by Q-tipped cotton test and visual analogue scale varied between studies. Placebo was shown to be as effective as any medication.There is a need for further studies evaluating topical monotherapy for the treatment of vulvodynia, as they are the main drugs used in clinical practice.No medication has shown impact on vulvar pain in vulvodynia. There is evidence of a placebo effect." @default.
• W2790174429 created "2018-03-29" @default.
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• W2790174429 date "2018-04-15" @default.
• W2790174429 modified "2023-10-15" @default.
• W2790174429 title "A systematic review of drug treatment of vulvodynia: evidence of a strong placebo effect" @default.
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• W2790174429 doi "https://doi.org/10.1111/1471-0528.15223" @default.
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