Matches in SemOpenAlex for { <https://semopenalex.org/work/W2790207230> ?p ?o ?g. }
- W2790207230 endingPage "305" @default.
- W2790207230 startingPage "294" @default.
- W2790207230 abstract "Zearalenone (ZEA), a metabolite of Fusarium fungi, is commonly found on moldy grains. Because it can competitively combine to estrogen receptor to disrupt estrogenic signaling, it has been reported to have serious adverse effects on animal reproduction systems. In order to explore the genotoxic effects of ZEA exposure on ovarian somatic cells, porcine granulosa cells were exposed to 10 μM and 30 μM ZEA for 24 or 72 h in vitro. The results showed that ZEA exposure for 24 h remarkably reduced the proliferation of porcine granulosa cells in a dose-dependent manner as determined by MTT analysis and flow cytometry. Furthermore, exposure to ZEA for 72 h induced apoptosis, and RNA sequence analysis also revealed that the expression of apoptosis related genes were altered. RT-qPCR, immunofluorescence and western blot analysis further confirmed the expression of DNA damage and repair related genes (γ-H2AX, BRCA1, RAD51 and PRKDC) were increased in ZEA exposed granulosa cells. When the estrogen antagonist, tamoxifen, was added with ZEA in the culture medium, the DNA damage and repairment by ZEA returned to normal level. Collectively, these results illustrate that ZEA disrupts genome stability and inhibits growth of porcine granulosa cells via the estrogen receptors which may promote granulosa cell apoptosis when the DNA repair system is not enough to rescue this serious damage." @default.
- W2790207230 created "2018-03-29" @default.
- W2790207230 creator A5001512334 @default.
- W2790207230 creator A5011777433 @default.
- W2790207230 creator A5029525035 @default.
- W2790207230 creator A5030942549 @default.
- W2790207230 creator A5033083323 @default.
- W2790207230 creator A5034182089 @default.
- W2790207230 creator A5040936421 @default.
- W2790207230 creator A5066738831 @default.
- W2790207230 creator A5077755009 @default.
- W2790207230 creator A5084297947 @default.
- W2790207230 date "2018-01-01" @default.
- W2790207230 modified "2023-10-03" @default.
- W2790207230 title "Mycotoxin zearalenone exposure impairs genomic stability of swine follicular granulosa cells <i>in vitro</i>" @default.
- W2790207230 cites W1723559853 @default.
- W2790207230 cites W1752089945 @default.
- W2790207230 cites W1779338497 @default.
- W2790207230 cites W1820466131 @default.
- W2790207230 cites W1950041953 @default.
- W2790207230 cites W1969643309 @default.
- W2790207230 cites W1972141494 @default.
- W2790207230 cites W1972710550 @default.
- W2790207230 cites W1989050867 @default.
- W2790207230 cites W1995368907 @default.
- W2790207230 cites W2001819193 @default.
- W2790207230 cites W2004397650 @default.
- W2790207230 cites W2010005082 @default.
- W2790207230 cites W2010711320 @default.
- W2790207230 cites W2015358791 @default.
- W2790207230 cites W2017175281 @default.
- W2790207230 cites W2026563125 @default.
- W2790207230 cites W2027849611 @default.
- W2790207230 cites W2029148348 @default.
- W2790207230 cites W2030094683 @default.
- W2790207230 cites W2035618305 @default.
- W2790207230 cites W2042166984 @default.
- W2790207230 cites W2047487859 @default.
- W2790207230 cites W2049970571 @default.
- W2790207230 cites W2051402439 @default.
- W2790207230 cites W2051412989 @default.
- W2790207230 cites W2055657437 @default.
- W2790207230 cites W2064469489 @default.
- W2790207230 cites W2064488040 @default.
- W2790207230 cites W2076558000 @default.
- W2790207230 cites W2077491931 @default.
- W2790207230 cites W2082559623 @default.
- W2790207230 cites W2083431317 @default.
- W2790207230 cites W2084586277 @default.
- W2790207230 cites W2086729257 @default.
- W2790207230 cites W2093351415 @default.
- W2790207230 cites W2097130665 @default.
- W2790207230 cites W2102226960 @default.
- W2790207230 cites W2102278945 @default.
- W2790207230 cites W2108234281 @default.
- W2790207230 cites W2111403239 @default.
- W2790207230 cites W2116468279 @default.
- W2790207230 cites W2117803941 @default.
- W2790207230 cites W2125667702 @default.
- W2790207230 cites W2131808731 @default.
- W2790207230 cites W2134526812 @default.
- W2790207230 cites W2135453449 @default.
- W2790207230 cites W2135540211 @default.
- W2790207230 cites W2137026987 @default.
- W2790207230 cites W2146979699 @default.
- W2790207230 cites W2147203421 @default.
- W2790207230 cites W2178637762 @default.
- W2790207230 cites W2179438025 @default.
- W2790207230 cites W2275523310 @default.
- W2790207230 cites W2470492287 @default.
- W2790207230 cites W251443338 @default.
- W2790207230 cites W2556443129 @default.
- W2790207230 cites W2561097644 @default.
- W2790207230 cites W2578802873 @default.
- W2790207230 cites W2620117134 @default.
- W2790207230 cites W2620765227 @default.
- W2790207230 cites W2622981013 @default.
- W2790207230 cites W2747526431 @default.
- W2790207230 cites W2747643593 @default.
- W2790207230 cites W2750311482 @default.
- W2790207230 cites W318672309 @default.
- W2790207230 cites W319040271 @default.
- W2790207230 cites W592112538 @default.
- W2790207230 doi "https://doi.org/10.7150/ijbs.23898" @default.
- W2790207230 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5859475" @default.
- W2790207230 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29559847" @default.
- W2790207230 hasPublicationYear "2018" @default.
- W2790207230 type Work @default.
- W2790207230 sameAs 2790207230 @default.
- W2790207230 citedByCount "47" @default.
- W2790207230 countsByYear W27902072302018 @default.
- W2790207230 countsByYear W27902072302019 @default.
- W2790207230 countsByYear W27902072302020 @default.
- W2790207230 countsByYear W27902072302021 @default.
- W2790207230 countsByYear W27902072302022 @default.
- W2790207230 countsByYear W27902072302023 @default.
- W2790207230 crossrefType "journal-article" @default.
- W2790207230 hasAuthorship W2790207230A5001512334 @default.