FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2790207478> ?p ?o ?g. }

• W2790207478 endingPage "18.2018" @default.
• W2790207478 startingPage "ENEURO.0021" @default.
• W2790207478 abstract "Abstract Dopamine has been suggested to be crucially involved in effort-related choices. Key findings are that dopamine depletion (i) changed preference for a high-cost, large-reward option to a low-cost, small-reward option, (ii) but not when the large-reward option was also low-cost or the small-reward option gave no reward, (iii) while increasing the latency in all the cases but only transiently, and (iv) that antagonism of either dopamine D1 or D2 receptors also specifically impaired selection of the high-cost, large-reward option. The underlying neural circuit mechanisms remain unclear. Here we show that findings i–iii can be explained by the dopaminergic representation of temporal-difference reward-prediction error (TD-RPE), whose mechanisms have now become clarified, if (1) the synaptic strengths storing the values of actions mildly decay in time and (2) the obtained-reward-representing excitatory input to dopamine neurons increases after dopamine depletion. The former is potentially caused by background neural activity–induced weak synaptic plasticity, and the latter is assumed to occur through post-depletion increase of neural activity in the pedunculopontine nucleus, where neurons representing obtained reward exist and presumably send excitatory projections to dopamine neurons. We further show that finding iv, which is nontrivial given the suggested distinct functions of the D1 and D2 corticostriatal pathways, can also be explained if we additionally assume a proposed mechanism of TD-RPE calculation, in which the D1 and D2 pathways encode the values of actions with a temporal difference. These results suggest a possible circuit mechanism for the involvements of dopamine in effort-related choices and, simultaneously, provide implications for the mechanisms of TD-RPE calculation." @default.
• W2790207478 created "2018-03-29" @default.
• W2790207478 creator A5004696682 @default.
• W2790207478 creator A5059387763 @default.
• W2790207478 date "2018-01-01" @default.
• W2790207478 modified "2023-10-03" @default.
• W2790207478 title "A Neural Circuit Mechanism for the Involvements of Dopamine in Effort-Related Choices: Decay of Learned Values, Secondary Effects of Depletion, and Calculation of Temporal Difference Error" @default.
• W2790207478 cites W1529770635 @default.
• W2790207478 cites W1581202840 @default.
• W2790207478 cites W1586845208 @default.
• W2790207478 cites W159677714 @default.
• W2790207478 cites W1607052939 @default.
• W2790207478 cites W1652173018 @default.
• W2790207478 cites W1842341093 @default.
• W2790207478 cites W1967039863 @default.
• W2790207478 cites W1968494348 @default.
• W2790207478 cites W1969392675 @default.
• W2790207478 cites W1971501199 @default.
• W2790207478 cites W1971999279 @default.
• W2790207478 cites W1977927688 @default.
• W2790207478 cites W1978506717 @default.
• W2790207478 cites W1982670892 @default.
• W2790207478 cites W1985771124 @default.
• W2790207478 cites W1988220777 @default.
• W2790207478 cites W1994984635 @default.
• W2790207478 cites W1995915560 @default.
• W2790207478 cites W1997128521 @default.
• W2790207478 cites W2003603884 @default.
• W2790207478 cites W2011451766 @default.
• W2790207478 cites W2011659276 @default.
• W2790207478 cites W2013349633 @default.
• W2790207478 cites W2022561563 @default.
• W2790207478 cites W2022633426 @default.
• W2790207478 cites W2029164808 @default.
• W2790207478 cites W2029383690 @default.
• W2790207478 cites W2031427673 @default.
• W2790207478 cites W2041848110 @default.
• W2790207478 cites W2044924321 @default.
• W2790207478 cites W2045289490 @default.
• W2790207478 cites W2046713808 @default.
• W2790207478 cites W2051609565 @default.
• W2790207478 cites W2053924161 @default.
• W2790207478 cites W2054475627 @default.
• W2790207478 cites W2058279623 @default.
• W2790207478 cites W2059749451 @default.
• W2790207478 cites W2064885604 @default.
• W2790207478 cites W2070898342 @default.
• W2790207478 cites W2073561633 @default.
• W2790207478 cites W2075604288 @default.
• W2790207478 cites W2077611535 @default.
• W2790207478 cites W2079150537 @default.
• W2790207478 cites W2085658907 @default.
• W2790207478 cites W2088602317 @default.
• W2790207478 cites W2089641976 @default.
• W2790207478 cites W2090500269 @default.
• W2790207478 cites W2091929703 @default.
• W2790207478 cites W2092279314 @default.
• W2790207478 cites W2110747461 @default.
• W2790207478 cites W2117277172 @default.
• W2790207478 cites W2117644734 @default.
• W2790207478 cites W2117726420 @default.
• W2790207478 cites W2118830830 @default.
• W2790207478 cites W2124901115 @default.
• W2790207478 cites W2126680030 @default.
• W2790207478 cites W2129399354 @default.
• W2790207478 cites W2136621137 @default.
• W2790207478 cites W2140634028 @default.
• W2790207478 cites W2142671349 @default.
• W2790207478 cites W2145982623 @default.
• W2790207478 cites W2147538742 @default.
• W2790207478 cites W2152681028 @default.
• W2790207478 cites W2156952192 @default.
• W2790207478 cites W2162580191 @default.
• W2790207478 cites W2211629969 @default.
• W2790207478 cites W2214962513 @default.
• W2790207478 cites W2220700876 @default.
• W2790207478 cites W2259239391 @default.
• W2790207478 cites W2263610200 @default.
• W2790207478 cites W2285539329 @default.
• W2790207478 cites W2339071900 @default.
• W2790207478 cites W2400105390 @default.
• W2790207478 cites W2411013142 @default.
• W2790207478 cites W2462697109 @default.
• W2790207478 cites W2474020094 @default.
• W2790207478 cites W2518664057 @default.
• W2790207478 cites W2531037093 @default.
• W2790207478 cites W2557083543 @default.
• W2790207478 cites W2582553588 @default.
• W2790207478 cites W2612356851 @default.
• W2790207478 cites W2612948662 @default.
• W2790207478 cites W2914656440 @default.
• W2790207478 cites W891896036 @default.
• W2790207478 doi "https://doi.org/10.1523/eneuro.0021-18.2018" @default.
• W2790207478 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5820541" @default.
• W2790207478 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29468191" @default.
• W2790207478 hasPublicationYear "2018" @default.
• W2790207478 type Work @default.
• W2790207478 sameAs 2790207478 @default.

• next