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• W2790228210 abstract "To test the short-term effectiveness of a mandibular advancement splint (MAS) for the management of sleep-disordered breathing (SDB) in children. Eighteen SDB children were enrolled in a crossover randomized clinical trial and assigned to a treatment sequence starting either with an Active or a Sham MAS. Each appliance was worn for three weeks and treatment periods were separated by a two-week washout. Home-based polysomnographic data were collected before and after each treatment period. In addition, blood samples were collected at the end of each treatment period to assess serum levels of insulin-like growth factor-1 (IGF-1). The apnea-hypopnea index (AHI) and snoring time represented the main outcome variables. Secondary outcomes included IGF-1 levels, and questionnaire scores for quality of life and behavior. Compared to the Sham MAS, the wearing of the Active MAS resulted in a significant reduction in overall AHI (-37%; 95% CI = 15–53%; p = 0.002) and supine AHI (−4.1 events per hour; 95% CI = 1.8–6.4; p < 0.001). Mean snoring time per night was shorter with the Active MAS than with the Sham MAS (−46.3 min; 95% CI = 14.5–78.1; p = 0.004). Wearing of the Active MAS improved the ratings of quality of life and behavior (P ≤ 0.028), but there was no evidence that it influenced IGF-1 levels (P = 0.172). Wearing an Active MAS overnight, over a short period can be beneficial for SDB children, resulting in a clinically relevant reduction of supine AHI." @default.
• W2790228210 created "2018-03-29" @default.
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• W2790228210 date "2018-04-01" @default.
• W2790228210 modified "2023-10-06" @default.
• W2790228210 title "Mandibular advancement appliances for sleep-disordered breathing in children: A randomized crossover clinical trial" @default.
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• W2790228210 doi "https://doi.org/10.1016/j.jdent.2018.01.006" @default.
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