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- W2790228595 abstract "INTRODUCTION :Colorectal carcinoma is a common cancer all over the world.Colorectal cancer ranks second in terms of both incidence & mortalityin more developed countries. Nearly 945,000 new colo-rectal cancerscases are diagnosed world wide each year and colo-rectal cancer isresponsible for some 492,000 deaths. There is significant geographicalvariation in age standardized incidence as well as in cumulative 0-74years incidence, high rates occurring in countries of Europe, NorthAmerica, Australia and Japan. For carcinoma rectum, the crude incidence rate per 100,000 populations inChennai, India and world for males are 3.0, 3.6, & 16.4 respectivelyand for females are 1.6, 2.6 and 14.8 respectively. The agestandardized rates per 100,000 population in Chennai, India and worldfor males are 3.7, 4.7, and 19% respectively and for females are 1.9,3.2 and 14.4 respectively. Geographicvariation in colorectal cancer incidence implies and to a large extentproves the critical nature of environmental factors. The incidence ratefor residents of Alaskan natives exceeds to 70 per 100,000. whereas that far residents of Gambia and Algeria is less than 2 per 100,000.The etiology of colorectal cancer is complex involving aninterplay of environmental and genetic factors. Familial factorscontribute to the risk of sporadic colorectal cancer. Involvement of atleast one first degree relative with colorectal cancer doubles the risk ofcolorectal cancer. There is further enhancement of the risk if such a relativeis affected before the age of 60yrs. Obesity and total caloric intakes are independent risk factors forrectal cancer. Ingestion of red meat isassociated with an increased risk of colorectal cancer. Fried,barbecued and processed meats are associated with rectal cancer, withan odds ratio of 6.AIMS & OBJECTIVES :1. Expression of cyclin A in normal rectal mucosa & rectalCarcinoma.2. Correlation of cyclin A over expression with stage & grade ofrectal carcinoma.3. Correlation of cyclin A over expression with response toneoadjuvant treatment and recurrence.CONCLUSION :Cyclin A expression is seen in normal rectal mucosa & it is overexpressed in rectal carcinoma.Cyclin A over expression is less in mucin secretingadenocarcinoma & signet ring cell carcinoma of rectum in comparisonto adeno carcinoma of rectum.The over expression of cyclin A is more in higher grade rectal carcinoma.As the primary tumor stage of rectal carcinoma increases theover expression of cyclin A also increases.Presence or absence of cyclin A over expression does notcorrelate response to neoadjuvant treatment.The correlation of recurrence of the rectal carcinoma afterneoadjuvant chemo-radiotherapy followed by surgery & cyclin A overexpression needs further evaluation in a large number of patients witha longer duration of follow up to come to a definitive conclusion." @default.
- W2790228595 created "2018-03-29" @default.
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- W2790228595 date "2006-02-01" @default.
- W2790228595 modified "2023-09-27" @default.
- W2790228595 title "Expression of Cyclin A in Rectal Mucosa and Rectal Carcinoma." @default.
- W2790228595 hasPublicationYear "2006" @default.
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