FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2790230897> ?p ?o ?g. }

• W2790230897 endingPage "8" @default.
• W2790230897 startingPage "1" @default.
• W2790230897 abstract "Pulmonary hypertension (PH) causes significant morbidity and mortality in children due to right ventricular (RV) failure. We sought to determine the effect of prostacyclin analogues on RV function assessed by echocardiography in children with PH. We conducted a retrospective cohort study of children with PH treated with a prostacyclin analogue (epoprostenol or treprostinil) between January 2001 and August 2015 at our center. Data were collected before initiation of treatment (baseline) and at 1-3 and 6-12 months after. Protocolized echocardiogram measurements including tricuspid annular plane systolic excursion (TAPSE) and RV global longitudinal strain were made with blinding to clinical information. Forty-nine individuals (65% female), aged 0-29 years at the time of prostacyclin initiation were included. Disease types included pulmonary arterial hypertension (idiopathic [35%], heritable [2%], and congenital heart disease-associated [18%]), developmental lung disease (43%), and chronic thromboembolic PH (2%). Participants received intravenous (IV) epoprostenol (14%) and IV/subcutaneous (SQ) (67%) or inhaled (18%) treprostinil. Over the study period, prostacyclin analogues were associated with improvement in TAPSE ( P = 0.007), RV strain ( P < 0.001), and qualitative RV function ( P = 0.037) by echocardiogram, and BNP ( P < 0.001), functional class ( P = 0.047) and 6-min walk distance ( P = 0.001). TAPSE and strain improved at early follow up ( P = 0.05 and P = 0.002, respectively) despite minimal RV pressure change. In children with PH, prostacyclin analogues are associated with an early and sustained improvement in RV function measured as TAPSE and strain as well as clinical markers of PH severity. RV strain may be a sensitive marker of RV function in this population." @default.
• W2790230897 created "2018-03-29" @default.
• W2790230897 creator A5003642180 @default.
• W2790230897 creator A5008004426 @default.
• W2790230897 creator A5016760942 @default.
• W2790230897 creator A5037019785 @default.
• W2790230897 creator A5047872453 @default.
• W2790230897 creator A5061150083 @default.
• W2790230897 creator A5066688315 @default.
• W2790230897 creator A5089963417 @default.
• W2790230897 date "2018-02-01" @default.
• W2790230897 modified "2023-10-17" @default.
• W2790230897 title "Right ventricular function mirrors clinical improvement with use of prostacyclin analogues in pediatric pulmonary hypertension" @default.
• W2790230897 cites W105003453 @default.
• W2790230897 cites W1156023876 @default.
• W2790230897 cites W1433073799 @default.
• W2790230897 cites W1555590330 @default.
• W2790230897 cites W1782992772 @default.
• W2790230897 cites W1892792214 @default.
• W2790230897 cites W1967286491 @default.
• W2790230897 cites W1967913082 @default.
• W2790230897 cites W1974879235 @default.
• W2790230897 cites W1993993540 @default.
• W2790230897 cites W2000936710 @default.
• W2790230897 cites W2002636102 @default.
• W2790230897 cites W2012371153 @default.
• W2790230897 cites W2012584288 @default.
• W2790230897 cites W2012974722 @default.
• W2790230897 cites W2017805629 @default.
• W2790230897 cites W2025885023 @default.
• W2790230897 cites W2030261760 @default.
• W2790230897 cites W2031683588 @default.
• W2790230897 cites W2032885711 @default.
• W2790230897 cites W2035113936 @default.
• W2790230897 cites W2076198557 @default.
• W2790230897 cites W2090147115 @default.
• W2790230897 cites W2090695432 @default.
• W2790230897 cites W2101213473 @default.
• W2790230897 cites W2102192501 @default.
• W2790230897 cites W2108864520 @default.
• W2790230897 cites W2119457416 @default.
• W2790230897 cites W2124588783 @default.
• W2790230897 cites W2128924125 @default.
• W2790230897 cites W2141987653 @default.
• W2790230897 cites W2144118419 @default.
• W2790230897 cites W2147096662 @default.
• W2790230897 cites W2183644045 @default.
• W2790230897 cites W2210545634 @default.
• W2790230897 cites W2269614825 @default.
• W2790230897 cites W2275960723 @default.
• W2790230897 cites W2302469436 @default.
• W2790230897 cites W2336878979 @default.
• W2790230897 cites W2462587845 @default.
• W2790230897 cites W2499653055 @default.
• W2790230897 cites W2520111962 @default.
• W2790230897 cites W2548159990 @default.
• W2790230897 cites W2582602949 @default.
• W2790230897 cites W2746358139 @default.
• W2790230897 cites W2911339676 @default.
• W2790230897 doi "https://doi.org/10.1177/2045894018759247" @default.
• W2790230897 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5843105" @default.
• W2790230897 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29480089" @default.
• W2790230897 hasPublicationYear "2018" @default.
• W2790230897 type Work @default.
• W2790230897 sameAs 2790230897 @default.
• W2790230897 citedByCount "18" @default.
• W2790230897 countsByYear W27902308972019 @default.
• W2790230897 countsByYear W27902308972020 @default.
• W2790230897 countsByYear W27902308972022 @default.
• W2790230897 countsByYear W27902308972023 @default.
• W2790230897 crossrefType "journal-article" @default.
• W2790230897 hasAuthorship W2790230897A5003642180 @default.
• W2790230897 hasAuthorship W2790230897A5008004426 @default.
• W2790230897 hasAuthorship W2790230897A5016760942 @default.
• W2790230897 hasAuthorship W2790230897A5037019785 @default.
• W2790230897 hasAuthorship W2790230897A5047872453 @default.
• W2790230897 hasAuthorship W2790230897A5061150083 @default.
• W2790230897 hasAuthorship W2790230897A5066688315 @default.
• W2790230897 hasAuthorship W2790230897A5089963417 @default.
• W2790230897 hasBestOaLocation W27902308971 @default.
• W2790230897 hasConcept C126322002 @default.
• W2790230897 hasConcept C164705383 @default.
• W2790230897 hasConcept C2776432619 @default.
• W2790230897 hasConcept C2780074459 @default.
• W2790230897 hasConcept C2780930700 @default.
• W2790230897 hasConcept C2781128415 @default.
• W2790230897 hasConcept C71924100 @default.
• W2790230897 hasConcept C75603125 @default.
• W2790230897 hasConceptScore W2790230897C126322002 @default.
• W2790230897 hasConceptScore W2790230897C164705383 @default.
• W2790230897 hasConceptScore W2790230897C2776432619 @default.
• W2790230897 hasConceptScore W2790230897C2780074459 @default.
• W2790230897 hasConceptScore W2790230897C2780930700 @default.
• W2790230897 hasConceptScore W2790230897C2781128415 @default.
• W2790230897 hasConceptScore W2790230897C71924100 @default.
• W2790230897 hasConceptScore W2790230897C75603125 @default.
• W2790230897 hasFunder F4320307053 @default.
• W2790230897 hasFunder F4320309555 @default.

• next