Matches in SemOpenAlex for { <https://semopenalex.org/work/W2790240577> ?p ?o ?g. }
- W2790240577 endingPage "15720" @default.
- W2790240577 startingPage "15705" @default.
- W2790240577 abstract "High-grade gliomas are the most threatening brain tumors due to aggressive proliferation and poor prognosis. Thus, utilizing genetic glioma biomarkers to forecast prognosis and guide clinical management is crucial. Procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 (PLOD3) modulates cancer progression and metastasis. However, its detailed function in cancer remains largely uninvestigated. PLOD3 expression was evaluated with real-time PCR in glioblastoma (GBM) cell lines and by Gene Expression Omnibus dataset analysis and immunohistochemistry of glioma tissues. We investigated the clinical use of PLOD3 for determining glioma prognosis. The biological roles of PLOD3 in proliferation, migration and invasion of GBM cells were studied both in vitro with wound-healing and transwell assays and in vivo using an orthotopic xenograft mouse model. Hypoxia and western blotting were applied to discover the molecular mechanisms underlying PLOD3 functions. PLOD3 mRNA and protein expression were upregulated in glioma tissues compared to normal brain tissues. PLOD3 overexpression was correlated with negative survival in glioma patients. PLOD3 silencing suppressed cell proliferation and induced G1 phase arrest through p53-independent regulation of the p21 pathway. Inhibition of PLOD3 in glioma cells decreased VEGF expression, migration and invasion by downregulating mesenchymal markers, including Snail and Twist. Notably, knockdown of PLOD3 inhibited HIF-1α accumulation via the ERK signaling pathway under hypoxia. Taken together, these discoveries reveal that PLOD3 is a potential therapeutic target in human gliomas." @default.
- W2790240577 created "2018-03-29" @default.
- W2790240577 creator A5001354705 @default.
- W2790240577 creator A5009397461 @default.
- W2790240577 creator A5032276026 @default.
- W2790240577 creator A5056558888 @default.
- W2790240577 creator A5061757095 @default.
- W2790240577 creator A5073820679 @default.
- W2790240577 date "2018-02-28" @default.
- W2790240577 modified "2023-10-15" @default.
- W2790240577 title "Overexpression of PLOD3 promotes tumor progression and poor prognosis in gliomas" @default.
- W2790240577 cites W1493048246 @default.
- W2790240577 cites W1584625755 @default.
- W2790240577 cites W1721183049 @default.
- W2790240577 cites W1893588436 @default.
- W2790240577 cites W1972546051 @default.
- W2790240577 cites W1978041336 @default.
- W2790240577 cites W1978675872 @default.
- W2790240577 cites W1979964213 @default.
- W2790240577 cites W1986709772 @default.
- W2790240577 cites W1988692970 @default.
- W2790240577 cites W1992112921 @default.
- W2790240577 cites W1996118868 @default.
- W2790240577 cites W2000170954 @default.
- W2790240577 cites W2002811594 @default.
- W2790240577 cites W2014087704 @default.
- W2790240577 cites W2028506395 @default.
- W2790240577 cites W2032031848 @default.
- W2790240577 cites W2033987226 @default.
- W2790240577 cites W2037915750 @default.
- W2790240577 cites W2038570809 @default.
- W2790240577 cites W2038949876 @default.
- W2790240577 cites W2044415369 @default.
- W2790240577 cites W2049132016 @default.
- W2790240577 cites W2053801955 @default.
- W2790240577 cites W2054409720 @default.
- W2790240577 cites W2056135332 @default.
- W2790240577 cites W2056753605 @default.
- W2790240577 cites W2058412949 @default.
- W2790240577 cites W2062265555 @default.
- W2790240577 cites W2069228304 @default.
- W2790240577 cites W2072258712 @default.
- W2790240577 cites W2076451690 @default.
- W2790240577 cites W2079174568 @default.
- W2790240577 cites W2079487111 @default.
- W2790240577 cites W2081137947 @default.
- W2790240577 cites W2084831115 @default.
- W2790240577 cites W2086014809 @default.
- W2790240577 cites W2090363526 @default.
- W2790240577 cites W2090416100 @default.
- W2790240577 cites W2096287682 @default.
- W2790240577 cites W2097486055 @default.
- W2790240577 cites W2098538891 @default.
- W2790240577 cites W2100303404 @default.
- W2790240577 cites W2101858690 @default.
- W2790240577 cites W2110711017 @default.
- W2790240577 cites W2119212619 @default.
- W2790240577 cites W2129512401 @default.
- W2790240577 cites W2132447564 @default.
- W2790240577 cites W2133873984 @default.
- W2790240577 cites W2139593382 @default.
- W2790240577 cites W2140607197 @default.
- W2790240577 cites W2141779562 @default.
- W2790240577 cites W2147016321 @default.
- W2790240577 cites W2151080483 @default.
- W2790240577 cites W2154589460 @default.
- W2790240577 cites W2160382843 @default.
- W2790240577 cites W2162262059 @default.
- W2790240577 cites W2166045847 @default.
- W2790240577 cites W2166469535 @default.
- W2790240577 cites W2169283220 @default.
- W2790240577 cites W2274529180 @default.
- W2790240577 cites W2305883580 @default.
- W2790240577 cites W2334333112 @default.
- W2790240577 cites W2337452960 @default.
- W2790240577 cites W2476542314 @default.
- W2790240577 cites W2516829090 @default.
- W2790240577 cites W2563384630 @default.
- W2790240577 doi "https://doi.org/10.18632/oncotarget.24594" @default.
- W2790240577 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5884658" @default.
- W2790240577 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29644003" @default.
- W2790240577 hasPublicationYear "2018" @default.
- W2790240577 type Work @default.
- W2790240577 sameAs 2790240577 @default.
- W2790240577 citedByCount "40" @default.
- W2790240577 countsByYear W27902405772018 @default.
- W2790240577 countsByYear W27902405772019 @default.
- W2790240577 countsByYear W27902405772020 @default.
- W2790240577 countsByYear W27902405772021 @default.
- W2790240577 countsByYear W27902405772022 @default.
- W2790240577 countsByYear W27902405772023 @default.
- W2790240577 crossrefType "journal-article" @default.
- W2790240577 hasAuthorship W2790240577A5001354705 @default.
- W2790240577 hasAuthorship W2790240577A5009397461 @default.
- W2790240577 hasAuthorship W2790240577A5032276026 @default.
- W2790240577 hasAuthorship W2790240577A5056558888 @default.
- W2790240577 hasAuthorship W2790240577A5061757095 @default.
- W2790240577 hasAuthorship W2790240577A5073820679 @default.