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• W2790243532 abstract "<br><b>Aims:</b> The utility of GATA3 immunohistochemistry (IHC) as an aid to the cytological diagnosis of metastatic breast carcinoma in fine needle aspiration (FNA) specimens was investigated. <b>Materials and Methods:</b> Cell block sections from 111 FNA cases of metastatic malignancy were stained for GATA3, including metastases from 43 breast and 44 nonmammary adenocarcinomas, 19 melanomas, 4 urothelial carcinomas, and 1 thyroid medullary carcinoma. Sites sampled included lymph nodes (87), bone (8), liver (5), lung (6), superficial masses (4), and pelvic mass (1). <b>Results:</b> Ninety-one percent (39/43) of metastatic breast carcinoma cases were positive for GATA3. All estrogen receptor (ER)-positive were also GATA3 positive cases. The majority (9/14; 64%) of ER-negative and 37% (3/8) of triple-negative cases were positive for GATA3. All nonmammary adenocarcinoma cases were negative with the exception of one case of metastatic pancreatic adenocarcinoma. Metastatic melanoma cases were all negative but 75% (3/4) urothelial carcinomas expressed GATA3. <b>Conclusions:</b> GATA3 IHC staining is a useful addition to IHC panels for FNA samples in specific settings such as distinguishing metastatic breast from lung carcinoma or melanoma.<br>" @default.
• W2790243532 created "2018-03-29" @default.
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• W2790243532 date "2018-01-01" @default.
• W2790243532 modified "2023-10-18" @default.
• W2790243532 title "Gata3 immunohistochemical staining is a useful marker for metastatic breast carcinoma in fine needle aspiration specimens" @default.
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• W2790243532 doi "https://doi.org/10.4103/joc.joc_132_17" @default.
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