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• W2790260146 abstract "Purpose To develop a new MRI method to detect and characterize brain abscesses using the CEST contrast inherently carried by bacterial cells, namely bacCEST. Methods Bacteria S. aureus (ATCC #49775) and F98 and 9L glioma cells were injected stereotactically in the brains of F344 rats to form abscesses and tumors. The CEST signals of brain abscesses ( n = 4) and tumors ( n = 7) were acquired using 2 B 1 values (i.e., 1 and 3 µT) and compared. The bacCEST signal of the brain abscesses in the rats ( n = 3) receiving ampicillin (intraperitoneal injection 40 mg/kg twice daily) was acquired before, 4 and 10 days after the treatment. Results The bacCEST signal of S. aureus was characterized in vitro as a strong and broad signal in the range of 1 to 4 ppm, with the maximum contrast occurring at 2.6 ppm. The CEST signal in S. aureus –induced brain abscesses was significantly higher than that of contralateral parenchyma ( p = .003). Moreover, thanks to their different B 1 independence, brain abscesses and tumors could be effectively differentiated ( p = .005) using ΔCEST(2.6 ppm, 3 µT − 1 µT), defined by the difference between the CEST signal (offset = 2.6 ppm) acquired using B 1 = 3 µT and that of 1 µT. In treated rats, bacCEST MRI could detect the response of bacteria as early as 4 days after the antibiotic treatment ( p = .035). Conclusion BacCEST MRI provides a new imaging method to detect, discriminate, and monitor bacterial infection in deep‐seated organs. Because no contrast agent is needed, such an approach has a great translational potential for detecting and monitoring bacterial infection in deep‐seated organs." @default.
• W2790260146 created "2018-03-29" @default.
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• W2790260146 date "2018-03-25" @default.
• W2790260146 modified "2023-10-16" @default.
• W2790260146 title "MRI detection of bacterial brain abscesses and monitoring of antibiotic treatment using bacCEST" @default.
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• W2790260146 doi "https://doi.org/10.1002/mrm.27180" @default.
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