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- W2790260761 abstract "Background: Diseases and health conditions have been classified according to anatomical site, etiological and clinical criteria. Physico-chemical mechanisms underlying the biology of diseases, such as the flow of energy through cells and tissues, have been often overlooked in classification systems. Objective: We propose a conceptual framework towards the development of an energy-oriented classification of diseases, based on the principles of physical-chemistry. Methods: A review of literature on the physical-chemistry of biological interactions in a number of diseases is traced from the point of view of the fluid and solid mechanics, electricity, and chemistry. Results: We found consistent evidence in literature of decreased or/and increased physical and chemical forces intertwined with biological processes of numerous diseases, which allowed the identification of mechanical, electric and chemical phenotypes of diseases. Discussion: Biological mechanisms of diseases need to be evaluated and integrated into more comprehensive theories that should account with principles of physics and chemistry. A hypothetical model is proposed relating the natural history of diseases to mechanical stress, electric field and chemical equilibria (ATP) changes. The present perspective towards an innovative disease classification may improve drug-repurposing strategies in the future." @default.
- W2790260761 created "2018-03-29" @default.
- W2790260761 creator A5016012559 @default.
- W2790260761 creator A5022457570 @default.
- W2790260761 creator A5066300220 @default.
- W2790260761 date "2018-02-28" @default.
- W2790260761 modified "2023-10-11" @default.
- W2790260761 title "Toward a Reasoned Classification of Diseases Using Physico-Chemical Based Phenotypes" @default.
- W2790260761 cites W115382728 @default.
- W2790260761 cites W1488453532 @default.
- W2790260761 cites W1502166624 @default.
- W2790260761 cites W1530768309 @default.
- W2790260761 cites W1533674371 @default.
- W2790260761 cites W1573174618 @default.
- W2790260761 cites W1576233671 @default.
- W2790260761 cites W1585890093 @default.
- W2790260761 cites W1603514971 @default.
- W2790260761 cites W163724465 @default.
- W2790260761 cites W1775368080 @default.
- W2790260761 cites W1858864780 @default.
- W2790260761 cites W1899872116 @default.
- W2790260761 cites W1912466591 @default.
- W2790260761 cites W1940618937 @default.
- W2790260761 cites W1942770069 @default.
- W2790260761 cites W1965628709 @default.
- W2790260761 cites W1965832173 @default.
- W2790260761 cites W1967296654 @default.
- W2790260761 cites W1969820557 @default.
- W2790260761 cites W1970283678 @default.
- W2790260761 cites W1970439021 @default.
- W2790260761 cites W1972415853 @default.
- W2790260761 cites W1972762681 @default.
- W2790260761 cites W1973699797 @default.
- W2790260761 cites W1975854213 @default.
- W2790260761 cites W1977307932 @default.
- W2790260761 cites W1980514241 @default.
- W2790260761 cites W1981237781 @default.
- W2790260761 cites W1984600164 @default.
- W2790260761 cites W1985940938 @default.
- W2790260761 cites W1987410341 @default.
- W2790260761 cites W1987922000 @default.
- W2790260761 cites W1989395582 @default.
- W2790260761 cites W1993257882 @default.
- W2790260761 cites W1993811771 @default.
- W2790260761 cites W1994443420 @default.
- W2790260761 cites W1996259832 @default.
- W2790260761 cites W1998309463 @default.
- W2790260761 cites W2003772961 @default.
- W2790260761 cites W2003863419 @default.
- W2790260761 cites W2006182674 @default.
- W2790260761 cites W2010072553 @default.
- W2790260761 cites W2012156170 @default.
- W2790260761 cites W2015572318 @default.
- W2790260761 cites W2015959856 @default.
- W2790260761 cites W2017269146 @default.
- W2790260761 cites W2018430156 @default.
- W2790260761 cites W2019453676 @default.
- W2790260761 cites W2019549311 @default.
- W2790260761 cites W2019613511 @default.
- W2790260761 cites W2020851684 @default.
- W2790260761 cites W2020993937 @default.
- W2790260761 cites W2021782736 @default.
- W2790260761 cites W2025100148 @default.
- W2790260761 cites W2029868249 @default.
- W2790260761 cites W2031540167 @default.
- W2790260761 cites W2034217588 @default.
- W2790260761 cites W2036074296 @default.
- W2790260761 cites W2036145275 @default.
- W2790260761 cites W2038498153 @default.
- W2790260761 cites W2040037410 @default.
- W2790260761 cites W2043943908 @default.
- W2790260761 cites W2048876555 @default.
- W2790260761 cites W2050079318 @default.
- W2790260761 cites W2053259763 @default.
- W2790260761 cites W2057766834 @default.
- W2790260761 cites W2061644128 @default.
- W2790260761 cites W2065293958 @default.
- W2790260761 cites W2067850904 @default.
- W2790260761 cites W2067931061 @default.
- W2790260761 cites W2069125243 @default.
- W2790260761 cites W2071069055 @default.
- W2790260761 cites W2071676502 @default.
- W2790260761 cites W2072107291 @default.
- W2790260761 cites W2072451938 @default.
- W2790260761 cites W2073649940 @default.
- W2790260761 cites W2073982324 @default.
- W2790260761 cites W2078228702 @default.
- W2790260761 cites W2078686109 @default.
- W2790260761 cites W2081505040 @default.
- W2790260761 cites W2081915659 @default.
- W2790260761 cites W2083559362 @default.
- W2790260761 cites W2084527887 @default.
- W2790260761 cites W2084631182 @default.
- W2790260761 cites W2084855318 @default.
- W2790260761 cites W2085320682 @default.
- W2790260761 cites W2085423748 @default.
- W2790260761 cites W2085664253 @default.
- W2790260761 cites W2091857355 @default.
- W2790260761 cites W2092433290 @default.
- W2790260761 cites W2094928078 @default.