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• W2790269968 abstract "Purpose To determine if the increased dentate nucleus signal intensity following six or more doses of a linear gadolinium-based contrast agent (GBCA) (gadopentetate dimeglumine) changes at follow-up examinations performed with a macrocyclic GBCA (gadobutrol). Materials and Methods This retrospective study included 13 patients with increased dentate nucleus signal intensity following at least six (range, 6–18) gadopentetate dimeglumine administrations who then underwent at least 12 months of follow-up imaging with multiple (range, 3–29) gadobutrol-enhanced magnetic resonance (MR) examinations. Dentate nucleus–to-pons and dentate nucleus–to–cerebellar peduncle signal intensity ratios were measured by two radiologists blinded to all patient information, and changes were analyzed by using the paired t test and linear regression. Results The mean dentate nucleus–to-pons and dentate nucleus–to–cerebellar peduncle signal intensity ratios increased after gadopentetate dimeglumine administration, from 0.98 ± 0.03 to 1.10 ± 0.03 (P < .0001) and from 0.98 ± 0.030 to 1.09 ± 0.02 (P < .0001), respectively. With gadobutrol, the mean dentate nucleus–to-pons and dentate nucleus–to–cerebellar peduncle signal intensity ratios decreased to 1.03 ± 0.03 and 1.02 ± 0.04, respectively (P < .0001). With use of a mixed effects model linear regression allowing for each patient to have a different y intercept, mean dentate nucleus–to-pons and dentate nucleus–to–cerebellar peduncle signal intensity ratios decreased with follow-up time (dentate nucleus–to-pons: slope = −0.2% per month [95% confidence interval: −0.0024, −0.0015], R2 = 0.58, P < .0001 for nonzero slope; dentate nucleus–to–cerebellar peduncle: slope = −0.2% per month [95% confidence interval: −0.0024, −0.0015], R2 = 0.61, P < .0001 for nonzero slope). Conclusion Dentate signal intensity increased with at least six gadopentetate dimeglumine–enhanced MR examinations and decreased after switching from a linear (gadopentetate dimeglumine) to a macrocyclic (gadobutrol) GBCA. © RSNA, 2018 Online supplemental material is available for this article." @default.
• W2790269968 created "2018-03-29" @default.
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• W2790269968 date "2018-06-01" @default.
• W2790269968 modified "2023-09-26" @default.
• W2790269968 title "Dentate Nucleus Signal Intensity Decrease on T1-weighted MR Images after Switching from Gadopentetate Dimeglumine to Gadobutrol" @default.
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• W2790269968 doi "https://doi.org/10.1148/radiol.2018171398" @default.
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