FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2790292583> ?p ?o ?g. }

• W2790292583 endingPage "723" @default.
• W2790292583 startingPage "715" @default.
• W2790292583 abstract "To determine the frequency of older Americans with epilepsy receiving concomitant prescriptions for antiepileptic drugs (AEDs) and non-epilepsy drugs (NEDs) which could result in significant pharmacokinetic (PK) interaction, and to assess the contributions of racial/ethnic, socioeconomic, and demographic factors.Retrospective analyses of 2008-2010 Medicare claims for a 5% random sample of beneficiaries ≥67 years old in 2009 augmented for minority representation. Prevalent cases had ≥1 ICD-9 345.x or ≥2 ICD-9 780.3x, and ≥1 AED. Among them, incident cases had no seizure/epilepsy claim codes nor AEDs in preceding 365 days. Drug claims for AEDs, and for the 50 most common NEDs within +/- 60 days of the index epilepsy date were tabulated. Interacting pairs of AEDs/NEDs were identified by literature review. Logistic regression models were used to examine factors affecting the likelihood of interaction risk.Interacting drug pairs affecting NED efficacy were found in 24.5% of incident, 39% of prevalent cases. Combinations affecting AED efficacy were found in 20.4% of incident, 29.3% of prevalent cases. Factors predicting higher interaction risk included having ≥ 1 comorbidity, being eligible for Part D low Income Subsidy, and not living in the northeastern US. Protective factors were Asian race/ethnicity, and treatment by a neurologist.A substantial portion of older epilepsy patients received NED-AED combinations that could cause important PK interactions. The lower frequency among incident vs. prevalent cases may reflect changes in prescribing practices. Avoidance of interacting AEDs is feasible for most persons because of the availability of newer drugs." @default.
• W2790292583 created "2018-03-29" @default.
• W2790292583 creator A5003401361 @default.
• W2790292583 creator A5015461885 @default.
• W2790292583 creator A5015671479 @default.
• W2790292583 creator A5016535621 @default.
• W2790292583 creator A5020909854 @default.
• W2790292583 creator A5025406437 @default.
• W2790292583 creator A5051341372 @default.
• W2790292583 creator A5079656957 @default.
• W2790292583 creator A5080424540 @default.
• W2790292583 date "2018-02-07" @default.
• W2790292583 modified "2023-10-03" @default.
• W2790292583 title "Risk of pharmacokinetic interactions between antiepileptic and other drugs in older persons and factors associated with risk" @default.
• W2790292583 cites W1565364436 @default.
• W2790292583 cites W1581120810 @default.
• W2790292583 cites W1887872564 @default.
• W2790292583 cites W1960629422 @default.
• W2790292583 cites W1967811065 @default.
• W2790292583 cites W1985757460 @default.
• W2790292583 cites W1997993986 @default.
• W2790292583 cites W2010680811 @default.
• W2790292583 cites W2011966376 @default.
• W2790292583 cites W2012197247 @default.
• W2790292583 cites W2015657796 @default.
• W2790292583 cites W2016028193 @default.
• W2790292583 cites W2031671734 @default.
• W2790292583 cites W2123177504 @default.
• W2790292583 cites W2129168200 @default.
• W2790292583 cites W2142593115 @default.
• W2790292583 cites W2143243043 @default.
• W2790292583 cites W2146222551 @default.
• W2790292583 cites W2154914124 @default.
• W2790292583 cites W2167050490 @default.
• W2790292583 cites W2586875536 @default.
• W2790292583 cites W2605419512 @default.
• W2790292583 doi "https://doi.org/10.1111/epi.14010" @default.
• W2790292583 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5844842" @default.
• W2790292583 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29411348" @default.
• W2790292583 hasPublicationYear "2018" @default.
• W2790292583 type Work @default.
• W2790292583 sameAs 2790292583 @default.
• W2790292583 citedByCount "17" @default.
• W2790292583 countsByYear W27902925832018 @default.
• W2790292583 countsByYear W27902925832019 @default.
• W2790292583 countsByYear W27902925832020 @default.
• W2790292583 countsByYear W27902925832021 @default.
• W2790292583 countsByYear W27902925832022 @default.
• W2790292583 countsByYear W27902925832023 @default.
• W2790292583 crossrefType "journal-article" @default.
• W2790292583 hasAuthorship W2790292583A5003401361 @default.
• W2790292583 hasAuthorship W2790292583A5015461885 @default.
• W2790292583 hasAuthorship W2790292583A5015671479 @default.
• W2790292583 hasAuthorship W2790292583A5016535621 @default.
• W2790292583 hasAuthorship W2790292583A5020909854 @default.
• W2790292583 hasAuthorship W2790292583A5025406437 @default.
• W2790292583 hasAuthorship W2790292583A5051341372 @default.
• W2790292583 hasAuthorship W2790292583A5079656957 @default.
• W2790292583 hasAuthorship W2790292583A5080424540 @default.
• W2790292583 hasBestOaLocation W27902925831 @default.
• W2790292583 hasConcept C118552586 @default.
• W2790292583 hasConcept C126322002 @default.
• W2790292583 hasConcept C137403100 @default.
• W2790292583 hasConcept C144024400 @default.
• W2790292583 hasConcept C147077947 @default.
• W2790292583 hasConcept C149923435 @default.
• W2790292583 hasConcept C151956035 @default.
• W2790292583 hasConcept C167135981 @default.
• W2790292583 hasConcept C187212893 @default.
• W2790292583 hasConcept C19165224 @default.
• W2790292583 hasConcept C2426938 @default.
• W2790292583 hasConcept C2778186239 @default.
• W2790292583 hasConcept C2778858636 @default.
• W2790292583 hasConcept C2779159551 @default.
• W2790292583 hasConcept C2779384505 @default.
• W2790292583 hasConcept C2908647359 @default.
• W2790292583 hasConcept C71924100 @default.
• W2790292583 hasConcept C98274493 @default.
• W2790292583 hasConcept C99454951 @default.
• W2790292583 hasConceptScore W2790292583C118552586 @default.
• W2790292583 hasConceptScore W2790292583C126322002 @default.
• W2790292583 hasConceptScore W2790292583C137403100 @default.
• W2790292583 hasConceptScore W2790292583C144024400 @default.
• W2790292583 hasConceptScore W2790292583C147077947 @default.
• W2790292583 hasConceptScore W2790292583C149923435 @default.
• W2790292583 hasConceptScore W2790292583C151956035 @default.
• W2790292583 hasConceptScore W2790292583C167135981 @default.
• W2790292583 hasConceptScore W2790292583C187212893 @default.
• W2790292583 hasConceptScore W2790292583C19165224 @default.
• W2790292583 hasConceptScore W2790292583C2426938 @default.
• W2790292583 hasConceptScore W2790292583C2778186239 @default.
• W2790292583 hasConceptScore W2790292583C2778858636 @default.
• W2790292583 hasConceptScore W2790292583C2779159551 @default.
• W2790292583 hasConceptScore W2790292583C2779384505 @default.
• W2790292583 hasConceptScore W2790292583C2908647359 @default.
• W2790292583 hasConceptScore W2790292583C71924100 @default.
• W2790292583 hasConceptScore W2790292583C98274493 @default.
• W2790292583 hasConceptScore W2790292583C99454951 @default.

• next