Matches in SemOpenAlex for { <https://semopenalex.org/work/W2790332017> ?p ?o ?g. }
- W2790332017 endingPage "773" @default.
- W2790332017 startingPage "762" @default.
- W2790332017 abstract "Plants produce specialized metabolites for their defence. However, specialist herbivores adapt to these compounds and use them for their own benefit. Plants attacked predominantly by specialists may be under selection to reduce or eliminate production of co-opted chemicals: the defence de-escalation hypothesis. We studied the evolution of pyrrolizidine alkaloids (PAs) in Apocynaceae, larval host plants for PA-adapted butterflies (Danainae, milkweed and clearwing butterflies), to test if the evolutionary pattern is consistent with de-escalation. We used the first PA biosynthesis specific enzyme (homospermidine synthase, HSS) as tool for reconstructing PA evolution. We found hss orthologues in diverse Apocynaceae species, not all of them known to produce PAs. The phylogenetic analysis showed a monophyletic origin of the putative hss sequences early in the evolution of one Apocynaceae lineage (the APSA clade). We found an hss pseudogene in Asclepias syriaca, a species known to produce cardiac glycosides but no PAs, and four losses of an HSS amino acid motif. APSA clade species are significantly more likely to be Danainae larval host plants than expected if all Apocynaceae species were equally likely to be exploited. Our findings are consistent with PA de-escalation as an adaptive response to specialist attack." @default.
- W2790332017 created "2018-03-29" @default.
- W2790332017 creator A5008811208 @default.
- W2790332017 creator A5040191595 @default.
- W2790332017 creator A5052487746 @default.
- W2790332017 creator A5059263321 @default.
- W2790332017 creator A5063379254 @default.
- W2790332017 creator A5076565212 @default.
- W2790332017 creator A5086082220 @default.
- W2790332017 creator A5091688180 @default.
- W2790332017 date "2018-02-26" @default.
- W2790332017 modified "2023-10-01" @default.
- W2790332017 title "Evolution of pyrrolizidine alkaloid biosynthesis in Apocynaceae: revisiting the defence de‐escalation hypothesis" @default.
- W2790332017 cites W1486329624 @default.
- W2790332017 cites W1875727809 @default.
- W2790332017 cites W1964744361 @default.
- W2790332017 cites W1964803183 @default.
- W2790332017 cites W1967008717 @default.
- W2790332017 cites W1971484621 @default.
- W2790332017 cites W1974527906 @default.
- W2790332017 cites W1975451479 @default.
- W2790332017 cites W1984624453 @default.
- W2790332017 cites W1986632843 @default.
- W2790332017 cites W1989428173 @default.
- W2790332017 cites W1994896760 @default.
- W2790332017 cites W1995858030 @default.
- W2790332017 cites W1998432252 @default.
- W2790332017 cites W2003011924 @default.
- W2790332017 cites W2004220269 @default.
- W2790332017 cites W2005536513 @default.
- W2790332017 cites W2007091631 @default.
- W2790332017 cites W2013277649 @default.
- W2790332017 cites W2015911443 @default.
- W2790332017 cites W2019926678 @default.
- W2790332017 cites W2020587057 @default.
- W2790332017 cites W2020970523 @default.
- W2790332017 cites W2022751627 @default.
- W2790332017 cites W2024240161 @default.
- W2790332017 cites W2025104256 @default.
- W2790332017 cites W2031920683 @default.
- W2790332017 cites W2038723016 @default.
- W2790332017 cites W2040648922 @default.
- W2790332017 cites W2043331140 @default.
- W2790332017 cites W2044854256 @default.
- W2790332017 cites W2048268260 @default.
- W2790332017 cites W2063001337 @default.
- W2790332017 cites W2070296547 @default.
- W2790332017 cites W2080920158 @default.
- W2790332017 cites W2089225468 @default.
- W2790332017 cites W2091113519 @default.
- W2790332017 cites W2092847059 @default.
- W2790332017 cites W2096525273 @default.
- W2790332017 cites W2096698507 @default.
- W2790332017 cites W2098357503 @default.
- W2790332017 cites W2101084482 @default.
- W2790332017 cites W2104302381 @default.
- W2790332017 cites W2108302734 @default.
- W2790332017 cites W2110392562 @default.
- W2790332017 cites W2112937332 @default.
- W2790332017 cites W2112951896 @default.
- W2790332017 cites W2114803177 @default.
- W2790332017 cites W2115567294 @default.
- W2790332017 cites W2121637502 @default.
- W2790332017 cites W2123125200 @default.
- W2790332017 cites W2136145671 @default.
- W2790332017 cites W2144606496 @default.
- W2790332017 cites W2145212870 @default.
- W2790332017 cites W2146386015 @default.
- W2790332017 cites W2148767729 @default.
- W2790332017 cites W2150407111 @default.
- W2790332017 cites W2157277050 @default.
- W2790332017 cites W2168696662 @default.
- W2790332017 cites W2180921482 @default.
- W2790332017 cites W2221129925 @default.
- W2790332017 cites W2331333790 @default.
- W2790332017 cites W2331737329 @default.
- W2790332017 cites W2398869128 @default.
- W2790332017 cites W2399232552 @default.
- W2790332017 cites W2491571943 @default.
- W2790332017 cites W2503430850 @default.
- W2790332017 cites W4231728540 @default.
- W2790332017 cites W4234797890 @default.
- W2790332017 doi "https://doi.org/10.1111/nph.15061" @default.
- W2790332017 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5873419" @default.
- W2790332017 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29479722" @default.
- W2790332017 hasPublicationYear "2018" @default.
- W2790332017 type Work @default.
- W2790332017 sameAs 2790332017 @default.
- W2790332017 citedByCount "21" @default.
- W2790332017 countsByYear W27903320172018 @default.
- W2790332017 countsByYear W27903320172019 @default.
- W2790332017 countsByYear W27903320172020 @default.
- W2790332017 countsByYear W27903320172021 @default.
- W2790332017 countsByYear W27903320172022 @default.
- W2790332017 countsByYear W27903320172023 @default.
- W2790332017 crossrefType "journal-article" @default.
- W2790332017 hasAuthorship W2790332017A5008811208 @default.
- W2790332017 hasAuthorship W2790332017A5040191595 @default.