Matches in SemOpenAlex for { <https://semopenalex.org/work/W2790341450> ?p ?o ?g. }
- W2790341450 endingPage "3112" @default.
- W2790341450 startingPage "3101" @default.
- W2790341450 abstract "Protein self-assembly into amyloid fibrils or highly hierarchical superstructures is closely linked to neurodegenerative pathologies as Alzheimer’s and Parkinson’s diseases. Moreover, protein assemblies also emerged as building blocks for bioinspired nanostructured materials. In both the above mentioned fields, the main challenge is to control the growth and properties of the final protein structure. This relies on a more fundamental understanding of how interactions between proteins can determine structures and functions of biomolecular aggregates. Here, we identify a striking effect of the hydration of the single human insulin molecule and solvent properties in controlling hydrophobicity/hydrophilicity, structures, and morphologies of a superstructure named spherulite, observed in connection to Alzheimer’s disease. Depending on the presence of ethanol, such structures can incorporate fluorescent molecules with different physicochemical features and span a range of mechanical properties and morphologies. A theoretical model providing a thorough comprehension of the experimental data is developed, highlighting a direct connection between the intimate physical protein–protein interactions, the growth, and the properties of the self-assembled superstructures. Our findings indicate structural variability as a general property for amyloid-like aggregates and not limited to fibrils. This knowledge is pivotal not only for developing effective strategies against pathological amyloids but also for providing a platform to design highly tunable biomaterials, alternative to elongated protein fibrils." @default.
- W2790341450 created "2018-03-29" @default.
- W2790341450 creator A5031110003 @default.
- W2790341450 creator A5032755518 @default.
- W2790341450 creator A5038826996 @default.
- W2790341450 creator A5040804836 @default.
- W2790341450 creator A5053725102 @default.
- W2790341450 creator A5070518688 @default.
- W2790341450 creator A5077027837 @default.
- W2790341450 creator A5087484656 @default.
- W2790341450 date "2018-02-28" @default.
- W2790341450 modified "2023-09-27" @default.
- W2790341450 title "Ethanol Controls the Self-Assembly and Mesoscopic Properties of Human Insulin Amyloid Spherulites" @default.
- W2790341450 cites W1521958691 @default.
- W2790341450 cites W1528511554 @default.
- W2790341450 cites W1578090159 @default.
- W2790341450 cites W1799355436 @default.
- W2790341450 cites W1829995796 @default.
- W2790341450 cites W1830667138 @default.
- W2790341450 cites W1868428796 @default.
- W2790341450 cites W1964976698 @default.
- W2790341450 cites W1970577444 @default.
- W2790341450 cites W1970586199 @default.
- W2790341450 cites W1972266607 @default.
- W2790341450 cites W1974790276 @default.
- W2790341450 cites W1978271981 @default.
- W2790341450 cites W1980014569 @default.
- W2790341450 cites W1981789517 @default.
- W2790341450 cites W1982126789 @default.
- W2790341450 cites W1990778194 @default.
- W2790341450 cites W1992744136 @default.
- W2790341450 cites W1997126459 @default.
- W2790341450 cites W1997449658 @default.
- W2790341450 cites W1997944660 @default.
- W2790341450 cites W1999313400 @default.
- W2790341450 cites W2001270910 @default.
- W2790341450 cites W2003173129 @default.
- W2790341450 cites W2004470794 @default.
- W2790341450 cites W2004774375 @default.
- W2790341450 cites W2008635979 @default.
- W2790341450 cites W2010462701 @default.
- W2790341450 cites W2014875724 @default.
- W2790341450 cites W2024683933 @default.
- W2790341450 cites W2026740342 @default.
- W2790341450 cites W2035539300 @default.
- W2790341450 cites W2038559728 @default.
- W2790341450 cites W2043833442 @default.
- W2790341450 cites W2043978343 @default.
- W2790341450 cites W2046275417 @default.
- W2790341450 cites W2050693275 @default.
- W2790341450 cites W2057256078 @default.
- W2790341450 cites W2070166910 @default.
- W2790341450 cites W2071557920 @default.
- W2790341450 cites W2074735251 @default.
- W2790341450 cites W2085024221 @default.
- W2790341450 cites W2085142174 @default.
- W2790341450 cites W2085715764 @default.
- W2790341450 cites W2088395760 @default.
- W2790341450 cites W2090628735 @default.
- W2790341450 cites W2091293700 @default.
- W2790341450 cites W2096316333 @default.
- W2790341450 cites W2108305553 @default.
- W2790341450 cites W2117537971 @default.
- W2790341450 cites W2128879174 @default.
- W2790341450 cites W2135701488 @default.
- W2790341450 cites W2136186114 @default.
- W2790341450 cites W2137029158 @default.
- W2790341450 cites W2138698547 @default.
- W2790341450 cites W2144535585 @default.
- W2790341450 cites W2147849702 @default.
- W2790341450 cites W2154157809 @default.
- W2790341450 cites W2155743743 @default.
- W2790341450 cites W2167353640 @default.
- W2790341450 cites W2167954729 @default.
- W2790341450 cites W2292862169 @default.
- W2790341450 cites W2314655596 @default.
- W2790341450 cites W2382261180 @default.
- W2790341450 cites W2473486712 @default.
- W2790341450 cites W2491458126 @default.
- W2790341450 cites W2519570990 @default.
- W2790341450 cites W2529838384 @default.
- W2790341450 cites W2537705522 @default.
- W2790341450 cites W2572424493 @default.
- W2790341450 cites W2617139971 @default.
- W2790341450 cites W2763249104 @default.
- W2790341450 cites W4210961063 @default.
- W2790341450 doi "https://doi.org/10.1021/acs.jpcb.8b01779" @default.
- W2790341450 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29488762" @default.
- W2790341450 hasPublicationYear "2018" @default.
- W2790341450 type Work @default.
- W2790341450 sameAs 2790341450 @default.
- W2790341450 citedByCount "25" @default.
- W2790341450 countsByYear W27903414502019 @default.
- W2790341450 countsByYear W27903414502020 @default.
- W2790341450 countsByYear W27903414502021 @default.
- W2790341450 countsByYear W27903414502022 @default.
- W2790341450 countsByYear W27903414502023 @default.
- W2790341450 crossrefType "journal-article" @default.