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• W2790341725 abstract "Purpose . This study aimed to investigate the underlying molecular mechanisms of Parkinson’s disease (PD) by bioinformatics. Methods . Using the microarray dataset GSE72267 from the Gene Expression Omnibus database, which included 40 blood samples from PD patients and 19 matched controls, differentially expressed genes (DEGs) were identified after data preprocessing, followed by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses. Protein-protein interaction (PPI) network, microRNA- (miRNA-) target regulatory network, and transcription factor- (TF-) target regulatory networks were constructed. Results . Of 819 DEGs obtained, 359 were upregulated and 460 were downregulated. Two GO terms, “rRNA processing” and “cytoplasm,” and two KEGG pathways, “metabolic pathways” and “TNF signaling pathway,” played roles in PD development. Intercellular adhesion molecule 1 ( ICAM1 ) was the hub node in the PPI network; hsa-miR-7-5p, hsa-miR-433-3p, and hsa-miR-133b participated in PD pathogenesis. Six TFs, including zinc finger and BTB domain-containing 7A, ovo-like transcriptional repressor 1, GATA-binding protein 3, transcription factor dp-1, SMAD family member 1, and quiescin sulfhydryl oxidase 1, were related to PD. Conclusions . “rRNA processing,” “cytoplasm,” “metabolic pathways,” and “TNF signaling pathway” were key pathways involved in PD. ICAM1 , hsa-miR-7-5p, hsa-miR-433-3p, hsa-miR-133b, and the abovementioned six TFs might play important roles in PD development." @default.
• W2790341725 created "2018-03-29" @default.
• W2790341725 creator A5054560949 @default.
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• W2790341725 date "2018-01-01" @default.
• W2790341725 modified "2023-10-17" @default.
• W2790341725 title "Microarray Analysis of the Molecular Mechanism Involved in Parkinson’s Disease" @default.
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• W2790341725 cites W1967111894 @default.
• W2790341725 cites W1967157989 @default.
• W2790341725 cites W1970621848 @default.
• W2790341725 cites W1971009462 @default.
• W2790341725 cites W1972349994 @default.
• W2790341725 cites W1981506621 @default.
• W2790341725 cites W1985972499 @default.
• W2790341725 cites W1986216002 @default.
• W2790341725 cites W1986288479 @default.
• W2790341725 cites W1989373140 @default.
• W2790341725 cites W1992696908 @default.
• W2790341725 cites W2003172650 @default.
• W2790341725 cites W2007086697 @default.
• W2790341725 cites W2017165199 @default.
• W2790341725 cites W2019028138 @default.
• W2790341725 cites W2022421870 @default.
• W2790341725 cites W2027406112 @default.
• W2790341725 cites W2032500449 @default.
• W2790341725 cites W2033250049 @default.
• W2790341725 cites W2037679604 @default.
• W2790341725 cites W2045338633 @default.
• W2790341725 cites W2047998870 @default.
• W2790341725 cites W2059498834 @default.
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• W2790341725 cites W206131021 @default.
• W2790341725 cites W2066398961 @default.
• W2790341725 cites W2071919400 @default.
• W2790341725 cites W2074744324 @default.
• W2790341725 cites W2077552045 @default.
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• W2790341725 cites W2105599008 @default.
• W2790341725 cites W2107281049 @default.
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• W2790341725 cites W2129584348 @default.
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• W2790341725 cites W2160478953 @default.
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• W2790341725 cites W2340005882 @default.
• W2790341725 cites W2408556131 @default.
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• W2790341725 doi "https://doi.org/10.1155/2018/1590465" @default.
• W2790341725 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5852864" @default.
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• W2790341725 hasPublicationYear "2018" @default.
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