Matches in SemOpenAlex for { <https://semopenalex.org/work/W2790358412> ?p ?o ?g. }
- W2790358412 endingPage "17" @default.
- W2790358412 startingPage "3" @default.
- W2790358412 abstract "Summary High‐throughput sequencing of the DNA/RNA encoding antibody heavy‐ and light‐chains is rapidly transforming the field of adaptive immunity. It can address key questions, including: (i) how the B‐cell repertoire differs in health and disease; and (ii) if it does differ, the point(s) in B‐cell development at which this occurs. The advent of technologies, such as whole‐genome sequencing, offers the chance to link abnormalities in the B‐cell antibody repertoire to specific genomic variants and polymorphisms. Here, we discuss the current research using B‐cell antibody repertoire sequencing in three polygenic autoimmune diseases where there is good evidence for a pathological role for B‐cells, namely systemic lupus erythematosus, multiple sclerosis and rheumatoid arthritis. These autoimmune diseases exhibit significantly skewed B‐cell receptor repertoires compared with healthy controls. Interestingly, some common repertoire defects are shared between diseases, such as elevated IGHV4‐34 gene usage. B‐cell clones have effectively been characterized and tracked between different tissues and blood in autoimmune disease. It has been hypothesized that these differences may signify differences in B‐cell tolerance; however, the mechanisms and implications of these defects are not clear." @default.
- W2790358412 created "2018-03-29" @default.
- W2790358412 creator A5001067070 @default.
- W2790358412 creator A5001478159 @default.
- W2790358412 creator A5049045028 @default.
- W2790358412 date "2018-04-16" @default.
- W2790358412 modified "2023-10-07" @default.
- W2790358412 title "Antibody repertoire analysis in polygenic autoimmune diseases" @default.
- W2790358412 cites W1249080388 @default.
- W2790358412 cites W1502342189 @default.
- W2790358412 cites W1516874144 @default.
- W2790358412 cites W1534517942 @default.
- W2790358412 cites W1555492257 @default.
- W2790358412 cites W1574482841 @default.
- W2790358412 cites W1599964077 @default.
- W2790358412 cites W1642392901 @default.
- W2790358412 cites W1650999727 @default.
- W2790358412 cites W1775259803 @default.
- W2790358412 cites W1906388760 @default.
- W2790358412 cites W1936939552 @default.
- W2790358412 cites W1967549232 @default.
- W2790358412 cites W1967908665 @default.
- W2790358412 cites W1968502147 @default.
- W2790358412 cites W1969592008 @default.
- W2790358412 cites W1969610426 @default.
- W2790358412 cites W1970688787 @default.
- W2790358412 cites W1972564604 @default.
- W2790358412 cites W1977009221 @default.
- W2790358412 cites W1979460828 @default.
- W2790358412 cites W1984046448 @default.
- W2790358412 cites W1985755391 @default.
- W2790358412 cites W1987677365 @default.
- W2790358412 cites W1993751574 @default.
- W2790358412 cites W1994402720 @default.
- W2790358412 cites W1998434376 @default.
- W2790358412 cites W2000746330 @default.
- W2790358412 cites W2001732361 @default.
- W2790358412 cites W2005038925 @default.
- W2790358412 cites W2007412943 @default.
- W2790358412 cites W2007686771 @default.
- W2790358412 cites W2009487195 @default.
- W2790358412 cites W2010957725 @default.
- W2790358412 cites W2014649886 @default.
- W2790358412 cites W2017191090 @default.
- W2790358412 cites W2020702073 @default.
- W2790358412 cites W2021616480 @default.
- W2790358412 cites W2027789508 @default.
- W2790358412 cites W2032430793 @default.
- W2790358412 cites W2033418370 @default.
- W2790358412 cites W2035334867 @default.
- W2790358412 cites W2040547343 @default.
- W2790358412 cites W2042606815 @default.
- W2790358412 cites W2043971515 @default.
- W2790358412 cites W2045144441 @default.
- W2790358412 cites W2045612961 @default.
- W2790358412 cites W2046383867 @default.
- W2790358412 cites W2050909253 @default.
- W2790358412 cites W2053457637 @default.
- W2790358412 cites W2054575907 @default.
- W2790358412 cites W2054686030 @default.
- W2790358412 cites W2055519354 @default.
- W2790358412 cites W2057338076 @default.
- W2790358412 cites W2057728325 @default.
- W2790358412 cites W2059494328 @default.
- W2790358412 cites W2064515577 @default.
- W2790358412 cites W2068012172 @default.
- W2790358412 cites W2068747743 @default.
- W2790358412 cites W2070701919 @default.
- W2790358412 cites W2071187241 @default.
- W2790358412 cites W2071532361 @default.
- W2790358412 cites W2071562052 @default.
- W2790358412 cites W2071899049 @default.
- W2790358412 cites W2074438676 @default.
- W2790358412 cites W2076198413 @default.
- W2790358412 cites W2078610240 @default.
- W2790358412 cites W2078744808 @default.
- W2790358412 cites W2080231208 @default.
- W2790358412 cites W2084547554 @default.
- W2790358412 cites W2087027341 @default.
- W2790358412 cites W2087265576 @default.
- W2790358412 cites W2087638630 @default.
- W2790358412 cites W2088004237 @default.
- W2790358412 cites W2094298397 @default.
- W2790358412 cites W2096898586 @default.
- W2790358412 cites W2100213817 @default.
- W2790358412 cites W2107184059 @default.
- W2790358412 cites W2107271221 @default.
- W2790358412 cites W2118994799 @default.
- W2790358412 cites W2120346567 @default.
- W2790358412 cites W2123909340 @default.
- W2790358412 cites W2125736142 @default.
- W2790358412 cites W2125900722 @default.
- W2790358412 cites W2127132484 @default.
- W2790358412 cites W2129840266 @default.
- W2790358412 cites W2133527269 @default.
- W2790358412 cites W2133964489 @default.
- W2790358412 cites W2138854899 @default.
- W2790358412 cites W2141301927 @default.