FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2790365557> ?p ?o ?g. }

• W2790365557 endingPage "1122" @default.
• W2790365557 startingPage "1114" @default.
• W2790365557 abstract "All known hepatitis B virus (HBV) genotypes occur in humans and hominoid Old World non-human primates (NHPs). The divergent woolly monkey HBV (WMHBV) forms another orthohepadnavirus species. The evolutionary origins of HBV are unclear.We analysed sera from 124 Brazilian monkeys collected during 2012-2016 for hepadnaviruses using molecular and serological tools, and conducted evolutionary analyses.We identified a novel orthohepadnavirus species in capuchin monkeys (capuchin monkey hepatitis B virus [CMHBV]). We found CMHBV-specific antibodies in five animals and high CMHBV concentrations in one animal. Non-inflammatory, probably chronic infection was consistent with an intact preCore domain, low genetic variability, core deletions in deep sequencing, and no elevated liver enzymes. Cross-reactivity of antisera against surface antigens suggested antigenic relatedness of HBV, CMHBV, and WMHBV. Infection-determining CMHBV surface peptides bound to the human HBV receptor (human sodium taurocholate co-transporting polypeptide), but preferentially interacted with the capuchin monkey receptor homologue. CMHBV and WMHBV pseudotypes infected human hepatoma cells via the human sodium taurocholate co-transporting polypeptide, and were poorly neutralised by HBV vaccine-derived antibodies, suggesting that cross-species infections may be possible. Ancestral state reconstructions and sequence distance comparisons associated HBV with humans, whereas primate hepadnaviruses as a whole were projected to NHP ancestors. Co-phylogenetic analyses yielded evidence for co-speciation of hepadnaviruses and New World NHP. Bayesian hypothesis testing yielded strong support for an association of the HBV stem lineage with hominoid ancestors. Neither CMHBV nor WMHBV was likely the ancestor of the divergent human HBV genotypes F/H found in American natives.Our data suggest ancestral co-speciation of hepadnaviruses and NHP, and an Old World origin of the divergent HBV genotypes F/H. The identification of a novel primate hepadnavirus offers new perspectives for urgently needed animal models of chronic hepatitis B.The origins of HBV are unclear. The new orthohepadnavirus species from Brazilian capuchin monkeys resembled HBV in elicited infection patterns and could infect human liver cells using the same receptor as HBV. Evolutionary analyses suggested that primate HBV-related viruses might have emerged in African ancestors of New World monkeys millions of years ago. HBV was associated with hominoid primates, including humans and apes, suggesting evolutionary origins of HBV before the formation of modern humans. HBV genotypes found in American natives were divergent from those found in American monkeys, and likely introduced along prehistoric human migration. Our results elucidate the evolutionary origins and dispersal of primate HBV, identify a new orthohepadnavirus reservoir, and enable new perspectives for animal models of hepatitis B." @default.
• W2790365557 created "2018-03-29" @default.
• W2790365557 creator A5006151816 @default.
• W2790365557 creator A5008450000 @default.
• W2790365557 creator A5011461272 @default.
• W2790365557 creator A5014052477 @default.
• W2790365557 creator A5014795077 @default.
• W2790365557 creator A5024873898 @default.
• W2790365557 creator A5024995579 @default.
• W2790365557 creator A5026738175 @default.
• W2790365557 creator A5030576100 @default.
• W2790365557 creator A5030711200 @default.
• W2790365557 creator A5031812055 @default.
• W2790365557 creator A5031840245 @default.
• W2790365557 creator A5035013556 @default.
• W2790365557 creator A5037256730 @default.
• W2790365557 creator A5038493510 @default.
• W2790365557 creator A5039280845 @default.
• W2790365557 creator A5043138178 @default.
• W2790365557 creator A5054170667 @default.
• W2790365557 creator A5062644021 @default.
• W2790365557 creator A5068107600 @default.
• W2790365557 creator A5072038891 @default.
• W2790365557 creator A5072789018 @default.
• W2790365557 creator A5073782617 @default.
• W2790365557 creator A5074647507 @default.
• W2790365557 creator A5085098159 @default.
• W2790365557 date "2018-06-01" @default.
• W2790365557 modified "2023-10-15" @default.
• W2790365557 title "A novel hepatitis B virus species discovered in capuchin monkeys sheds new light on the evolution of primate hepadnaviruses" @default.
• W2790365557 cites W1040122842 @default.
• W2790365557 cites W1885313130 @default.
• W2790365557 cites W1967890666 @default.
• W2790365557 cites W1968502796 @default.
• W2790365557 cites W1973271690 @default.
• W2790365557 cites W1978097327 @default.
• W2790365557 cites W1989350663 @default.
• W2790365557 cites W2001228988 @default.
• W2790365557 cites W2006701997 @default.
• W2790365557 cites W2008933169 @default.
• W2790365557 cites W2011052697 @default.
• W2790365557 cites W2016906953 @default.
• W2790365557 cites W2019719889 @default.
• W2790365557 cites W2022120248 @default.
• W2790365557 cites W2032161987 @default.
• W2790365557 cites W2048959160 @default.
• W2790365557 cites W2053060446 @default.
• W2790365557 cites W2054273522 @default.
• W2790365557 cites W2064625507 @default.
• W2790365557 cites W2076385002 @default.
• W2790365557 cites W2085154250 @default.
• W2790365557 cites W2086853608 @default.
• W2790365557 cites W2089991263 @default.
• W2790365557 cites W2090542340 @default.
• W2790365557 cites W2090862131 @default.
• W2790365557 cites W2094002760 @default.
• W2790365557 cites W2102369811 @default.
• W2790365557 cites W2105574681 @default.
• W2790365557 cites W2120426460 @default.
• W2790365557 cites W2130362098 @default.
• W2790365557 cites W2137661705 @default.
• W2790365557 cites W2138798117 @default.
• W2790365557 cites W2140177443 @default.
• W2790365557 cites W2140251504 @default.
• W2790365557 cites W2144476088 @default.
• W2790365557 cites W2145298459 @default.
• W2790365557 cites W2147058388 @default.
• W2790365557 cites W2150184039 @default.
• W2790365557 cites W2152207030 @default.
• W2790365557 cites W2159588987 @default.
• W2790365557 cites W2161845487 @default.
• W2790365557 cites W2166142062 @default.
• W2790365557 cites W2168630917 @default.
• W2790365557 cites W2169796429 @default.
• W2790365557 cites W2223286010 @default.
• W2790365557 cites W2277689306 @default.
• W2790365557 cites W2346926796 @default.
• W2790365557 cites W2406974152 @default.
• W2790365557 cites W2469290580 @default.
• W2790365557 cites W2565189107 @default.
• W2790365557 cites W2575914858 @default.
• W2790365557 cites W2588372153 @default.
• W2790365557 cites W2753903906 @default.
• W2790365557 cites W4211177544 @default.
• W2790365557 cites W4236084664 @default.
• W2790365557 doi "https://doi.org/10.1016/j.jhep.2018.01.029" @default.
• W2790365557 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29428874" @default.
• W2790365557 hasPublicationYear "2018" @default.
• W2790365557 type Work @default.
• W2790365557 sameAs 2790365557 @default.
• W2790365557 citedByCount "55" @default.
• W2790365557 countsByYear W27903655572018 @default.
• W2790365557 countsByYear W27903655572019 @default.
• W2790365557 countsByYear W27903655572020 @default.
• W2790365557 countsByYear W27903655572021 @default.
• W2790365557 countsByYear W27903655572022 @default.
• W2790365557 countsByYear W27903655572023 @default.
• W2790365557 crossrefType "journal-article" @default.

• next