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• W2790371678 abstract "Despite intense investigative interest over the last 3 decades relating to the proinflammatory response of severe infection, the treatment of sepsis remains targeted toward medical and surgical treatment of the infection nidus and support of organ dysfunction.’* Therapy can be divided into immediate steps taken to stabilize the patient, followed by more definitive therapeutic intervention. Other diseases and states may mimic sepsis and need to be considered during the initial evaluation. A wide variety of organisms may be associated with sepsis. Hypotension and hypoperfusion accompany severe sepsis and septic shock and warrant intense efforts to optimize organ perfusion. Other supportive care issues, such as stress ulcer prophylaxis and nutritional support, are important adjuncts to therapy. IMMEDIATE STABILIZATION The initial treatment priority in patients with severe sepsis is reversal of life-threatening (the ABCs: airway, breathing circulation) abnormalities. Altered mental status or depressed level of consciousness secondary to severe sepsis may require that a patient‘s airway be protected urgently. Pulmonary capillary leak may necessitate intubation to deliver higher oxygen concentrations or to allow the institution of mechanical ventilation to institute positive end-expiratory pressure (PEEP). Mechanical ventilation is expected to decrease oxygen consumption by the respiratory muscles and increase oxygen availability for other tissues. A decision to intubate must be weighed against potential complications of an artificial airway, including failure to properly intubate, upper airway injury, barotrauma, and hospital-acquired pneumonia. Circulation may be compromised early in severe sepsis. Sigruficant decreases in blood pressure may necessitate aggressive combined empiric therapy with fluids, inotropes, and vasopressors to reverse or ameliorate organ hypoperfusion pending more defini" @default.
• W2790371678 created "2018-03-29" @default.
• W2790371678 creator A5002389347 @default.
• W2790371678 date "1999-01-01" @default.
• W2790371678 modified "2023-09-26" @default.
• W2790371678 title "CU~ENT THERAPY FOR SEPSIS" @default.
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