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• W2790377788 endingPage "153303381876220" @default.
• W2790377788 startingPage "153303381876220" @default.
• W2790377788 abstract "Diverse thermal ablative therapies are currently in use for the treatment of cancer. Commonly applied with the intent to cure, these ablative therapies are providing promising success rates similar to and often exceeding gold standard approaches. Cancer-curing prospects may be enhanced by deeper understanding of thermal effects on cancer cells and the hosting tissue, including the molecular mechanisms of cancer cell mutations, which enable resistance to therapy. Furthermore, thermal ablative therapies may benefit from recent developments in computer hardware and computation tools for planning, monitoring, visualization, and education.Recent discoveries in cancer cell resistance to destruction by apoptosis, autophagy, and necrosis are now providing an understanding of the strategies used by cancer cells to avoid destruction by immunologic surveillance. Further, these discoveries are now providing insight into the success of the diverse types of ablative therapies utilized in the clinical arena today and into how they directly and indirectly overcome many of the cancers' defensive strategies. Additionally, the manner in which minimally invasive thermal therapy is enabled by imaging, which facilitates anatomical features reconstruction, insertion guidance of thermal probes, and strategic placement of thermal sensors, plays a critical role in the delivery of effective ablative treatment.The thermal techniques discussed include radiofrequency, microwave, high-intensity focused ultrasound, laser, and cryosurgery. Also discussed is the development of thermal adjunctive therapies-the combination of drug and thermal treatments-which provide new and more effective combinatorial physical and molecular-based approaches for treating various cancers. Finally, advanced computational and planning tools are also discussed.This review lays out the various molecular adaptive mechanisms-the hallmarks of cancer-responsible for therapeutic resistance, on one hand, and how various ablative therapies, including both heating- and freezing-based strategies, overcome many of cancer's defenses, on the other hand, thereby enhancing the potential for curative approaches for various cancers." @default.
• W2790377788 created "2018-03-29" @default.
• W2790377788 creator A5003610672 @default.
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• W2790377788 creator A5009687747 @default.
• W2790377788 creator A5015788130 @default.
• W2790377788 creator A5044303961 @default.
• W2790377788 creator A5069089326 @default.
• W2790377788 date "2018-01-01" @default.
• W2790377788 modified "2023-09-30" @default.
• W2790377788 title "Defeating Cancers’ Adaptive Defensive Strategies Using Thermal Therapies: Examining Cancer’s Therapeutic Resistance, Ablative, and Computational Modeling Strategies as a means for Improving Therapeutic Outcome" @default.
• W2790377788 cites W143764685 @default.
• W2790377788 cites W1480706413 @default.
• W2790377788 cites W1482884455 @default.
• W2790377788 cites W1487210925 @default.
• W2790377788 cites W1490795708 @default.
• W2790377788 cites W1492530790 @default.
• W2790377788 cites W1495672122 @default.
• W2790377788 cites W1527182291 @default.
• W2790377788 cites W1534849470 @default.
• W2790377788 cites W1607795111 @default.
• W2790377788 cites W1948181060 @default.
• W2790377788 cites W1964989417 @default.
• W2790377788 cites W1965038309 @default.
• W2790377788 cites W1965142411 @default.
• W2790377788 cites W1965743177 @default.
• W2790377788 cites W1966046861 @default.
• W2790377788 cites W1966830428 @default.
• W2790377788 cites W1967138033 @default.
• W2790377788 cites W1967532587 @default.
• W2790377788 cites W1967970002 @default.
• W2790377788 cites W1970126632 @default.
• W2790377788 cites W1972686536 @default.
• W2790377788 cites W1973269120 @default.
• W2790377788 cites W1975211715 @default.
• W2790377788 cites W1977447085 @default.
• W2790377788 cites W1977498852 @default.
• W2790377788 cites W1980896156 @default.
• W2790377788 cites W1982003465 @default.
• W2790377788 cites W1982745865 @default.
• W2790377788 cites W1982974502 @default.
• W2790377788 cites W1983501452 @default.
• W2790377788 cites W1983615147 @default.
• W2790377788 cites W1983624489 @default.
• W2790377788 cites W1983934840 @default.
• W2790377788 cites W1985256611 @default.
• W2790377788 cites W1985549756 @default.
• W2790377788 cites W1985804036 @default.
• W2790377788 cites W1988210408 @default.
• W2790377788 cites W1988457534 @default.
• W2790377788 cites W1991714918 @default.
• W2790377788 cites W1991755279 @default.
• W2790377788 cites W1991942227 @default.
• W2790377788 cites W1996052186 @default.
• W2790377788 cites W1996480534 @default.
• W2790377788 cites W1997857177 @default.
• W2790377788 cites W1999657696 @default.
• W2790377788 cites W2000299716 @default.
• W2790377788 cites W2000367283 @default.
• W2790377788 cites W2000664040 @default.
• W2790377788 cites W2002932050 @default.
• W2790377788 cites W2003370479 @default.
• W2790377788 cites W2004878973 @default.
• W2790377788 cites W2005961460 @default.
• W2790377788 cites W2006367870 @default.
• W2790377788 cites W2009194887 @default.
• W2790377788 cites W2009886857 @default.
• W2790377788 cites W2011874271 @default.
• W2790377788 cites W2012070204 @default.
• W2790377788 cites W2013971175 @default.
• W2790377788 cites W2014058353 @default.
• W2790377788 cites W2015077229 @default.
• W2790377788 cites W2016710684 @default.
• W2790377788 cites W2017514855 @default.
• W2790377788 cites W2018116689 @default.
• W2790377788 cites W2018995583 @default.
• W2790377788 cites W2019075849 @default.
• W2790377788 cites W2020168722 @default.
• W2790377788 cites W2022946817 @default.
• W2790377788 cites W2023088479 @default.
• W2790377788 cites W2023859532 @default.
• W2790377788 cites W2024934637 @default.
• W2790377788 cites W2026216143 @default.
• W2790377788 cites W2028098481 @default.
• W2790377788 cites W2028415754 @default.
• W2790377788 cites W2029087248 @default.
• W2790377788 cites W2030103235 @default.
• W2790377788 cites W2030694165 @default.
• W2790377788 cites W2030794485 @default.
• W2790377788 cites W2032575813 @default.
• W2790377788 cites W2032701002 @default.
• W2790377788 cites W2035983112 @default.
• W2790377788 cites W2040263267 @default.
• W2790377788 cites W2041783360 @default.
• W2790377788 cites W2042669918 @default.
• W2790377788 cites W2043175101 @default.
• W2790377788 cites W2045615009 @default.
• W2790377788 cites W2046839370 @default.

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