FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2790398503> ?p ?o ?g. }

• W2790398503 endingPage "e0191848" @default.
• W2790398503 startingPage "e0191848" @default.
• W2790398503 abstract "Objective To describe antiretroviral therapy (ART) adherence and associated factors for a large HIV-infected pediatric cohort followed by sites of the East Africa International Epidemiologic Databases to Evaluate AIDS (IeDEA) consortium. Methods This study utilized prospectively collected clinical data from HIV-infected children less than 13 years of age who initiated ART within 4 clinical care programs (with 26 clinical sites) in Kenya, Uganda, and Tanzania and were followed for up to 6 years. Programs used one of 3 adherence measures, including 7-day quantitative recall, 7-day categorical recall, and clinician pill assessments. We fit a hierarchical, three-level, logistic-regression model to examine adherence, with observations nested within patient, and patients within the 26 sites providing pediatric HIV data to this analysis. Results In East Africa, 3,304 children, 52.0% male, were enrolled in care and were subsequently observed for a median of 92 weeks (inter-quartile range [IQR] 50.3–145.0 weeks). Median age at ART initiation was 5.5 years ([IQR] 3.0–8.5 years). “Good” adherence, as reported by each clinic’s measures, was extremely high, remaining on average above 90% throughout all years of follow-up. Longer time on ART was associated with higher adherence (adjusted Odds Ratio–aOR–per log-transformed week on ART: 1.095, 95% Confidence Interval–CI–[1.052–1.150].) Patients enrolled in higher-volume programs exhibited higher rates of clinician-assessed adherence (aOR per log-500 patients: 1.174, 95% CI [1.108–1.245]). Significant site-level variability in reported adherence was observed (0.28), with even higher variability among patients (0.71). In a sub-analysis, being an orphan at the start of ART was strongly associated with lower ART adherence rates (aOR: 0.919, 95% CI [0.864–0.976]). Conclusions Self-reported adherence remained high over a median of 1.8 years in HIV care, but varied according to patient-level and site-level factors. Consistent adherence monitoring with validated measures and attention to vulnerable groups is recommended." @default.
• W2790398503 created "2018-03-29" @default.
• W2790398503 creator A5011315383 @default.
• W2790398503 creator A5017588392 @default.
• W2790398503 creator A5020343141 @default.
• W2790398503 creator A5024622118 @default.
• W2790398503 creator A5043031415 @default.
• W2790398503 creator A5055518070 @default.
• W2790398503 creator A5059878540 @default.
• W2790398503 creator A5074736567 @default.
• W2790398503 creator A5087624117 @default.
• W2790398503 date "2018-02-21" @default.
• W2790398503 modified "2023-10-14" @default.
• W2790398503 title "Adherence to antiretroviral therapy in a clinical cohort of HIV-infected children in East Africa" @default.
• W2790398503 cites W1961129808 @default.
• W2790398503 cites W1966271258 @default.
• W2790398503 cites W1969298111 @default.
• W2790398503 cites W1972972113 @default.
• W2790398503 cites W1973637875 @default.
• W2790398503 cites W1982612158 @default.
• W2790398503 cites W1983300335 @default.
• W2790398503 cites W1987617918 @default.
• W2790398503 cites W1993062623 @default.
• W2790398503 cites W1997006108 @default.
• W2790398503 cites W1999528036 @default.
• W2790398503 cites W2003535413 @default.
• W2790398503 cites W2005087233 @default.
• W2790398503 cites W2010861965 @default.
• W2790398503 cites W2020930666 @default.
• W2790398503 cites W2022066569 @default.
• W2790398503 cites W2028921104 @default.
• W2790398503 cites W2031551729 @default.
• W2790398503 cites W2033009730 @default.
• W2790398503 cites W2034323552 @default.
• W2790398503 cites W2037635462 @default.
• W2790398503 cites W2038723027 @default.
• W2790398503 cites W2039340262 @default.
• W2790398503 cites W2039596291 @default.
• W2790398503 cites W2040027667 @default.
• W2790398503 cites W2042085468 @default.
• W2790398503 cites W2044621133 @default.
• W2790398503 cites W2054015555 @default.
• W2790398503 cites W2066835269 @default.
• W2790398503 cites W2074076209 @default.
• W2790398503 cites W2078206453 @default.
• W2790398503 cites W2079432484 @default.
• W2790398503 cites W2080850550 @default.
• W2790398503 cites W2081581685 @default.
• W2790398503 cites W2086933264 @default.
• W2790398503 cites W2090796588 @default.
• W2790398503 cites W2091339800 @default.
• W2790398503 cites W2092465023 @default.
• W2790398503 cites W2095706156 @default.
• W2790398503 cites W2102326515 @default.
• W2790398503 cites W2119218670 @default.
• W2790398503 cites W2120424188 @default.
• W2790398503 cites W2123764335 @default.
• W2790398503 cites W2133262300 @default.
• W2790398503 cites W2135444187 @default.
• W2790398503 cites W2144304933 @default.
• W2790398503 cites W2153826347 @default.
• W2790398503 cites W2156330207 @default.
• W2790398503 cites W2161379282 @default.
• W2790398503 cites W2163264029 @default.
• W2790398503 cites W2171618626 @default.
• W2790398503 cites W2172275045 @default.
• W2790398503 cites W2174327850 @default.
• W2790398503 cites W2249417149 @default.
• W2790398503 cites W2412116011 @default.
• W2790398503 cites W2792467716 @default.
• W2790398503 doi "https://doi.org/10.1371/journal.pone.0191848" @default.
• W2790398503 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5842873" @default.
• W2790398503 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29466385" @default.
• W2790398503 hasPublicationYear "2018" @default.
• W2790398503 type Work @default.
• W2790398503 sameAs 2790398503 @default.
• W2790398503 citedByCount "18" @default.
• W2790398503 countsByYear W27903985032019 @default.
• W2790398503 countsByYear W27903985032020 @default.
• W2790398503 countsByYear W27903985032021 @default.
• W2790398503 countsByYear W27903985032022 @default.
• W2790398503 countsByYear W27903985032023 @default.
• W2790398503 crossrefType "journal-article" @default.
• W2790398503 hasAuthorship W2790398503A5011315383 @default.
• W2790398503 hasAuthorship W2790398503A5017588392 @default.
• W2790398503 hasAuthorship W2790398503A5020343141 @default.
• W2790398503 hasAuthorship W2790398503A5024622118 @default.
• W2790398503 hasAuthorship W2790398503A5043031415 @default.
• W2790398503 hasAuthorship W2790398503A5055518070 @default.
• W2790398503 hasAuthorship W2790398503A5059878540 @default.
• W2790398503 hasAuthorship W2790398503A5074736567 @default.
• W2790398503 hasAuthorship W2790398503A5087624117 @default.
• W2790398503 hasBestOaLocation W27903985031 @default.
• W2790398503 hasConcept C119060515 @default.
• W2790398503 hasConcept C126322002 @default.
• W2790398503 hasConcept C142462285 @default.
• W2790398503 hasConcept C144024400 @default.
• W2790398503 hasConcept C149923435 @default.

• next