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• W2790409009 abstract "Tris (1, 3-dichloro-2-propyl) phosphate (TDCIPP), an extensively used organophosphorus flame retardant, is frequently detected in various environmental media and biota, and has been demonstrated as neurotoxic. Autophagy has been proposed as a protective mechanism against toxicant-induced neurotoxicity. The purpose of the present study was to investigate the effect of TDCIPP exposure on autophagy, and its role in TDCIPP-induced developmental neurotoxicity. Zebrafish embryos (2-120 h post-fertilization [hpf]) were exposed to TDCIPP (0, 5, 50 and 500 μg/l) and a model neurotoxic chemical, chlorpyrifos (CPF, 100 μg/l). The developmental endpoints, locomotive behavior, cholinesterase activities, gene and protein expression related to neurodevelopment and autophagy were measured in the larvae. Our results demonstrate that exposure to TDCIPP (500 μg/l) and CPF causes developmental toxicity, including reduced hatching and survival rates and increased malformation rate (e.g., spinal curvature), as well as altered locomotor behavior. The expression of selected neurodevelopmental gene and protein markers (e.g., mbp, syn2a, and α1-tubulin) was significantly down-regulated in CPF and TDCIPP exposed zebrafish larvae. Treatment with CPF significantly inhibits AChE and BChE, while TDCIPP (0-500 μg/l) exerts no effects on these enzymes. Furthermore, the conversion of microtubule-associated protein I (LC3 I) to LC3 II was significantly increased in TDCIPP exposed zebrafish larvae. In addition, exposure to TDCIPP also activates transcription of several critical genes in autophagy (e.g. Becn1, atg3, atg5, map1lc3b and sqstm1). To further investigate the role of autophagy in TDCIPP induced developmental neurotoxicity, an autophagy inducer (rapamycin, Rapa, 1 nM) and inhibitor (chloroquine, CQ, 1 μM) were used. The results demonstrate that the hatching rate, survival rate, and the expression of mbp and а1-tubulin proteins were all significantly increased in larvae treated with TDCIPP (500 μg/l) and Rapa compared to TDCIPP alone. In contrast, co-treatment with the autophagy inhibitor CQ results in exacerbated neurodevelopmental toxicity. Taken together, our results confirm that exposure to TDCIPP induces autophagy, which plays a protective role in TDCIPP-induced developmental neurotoxicity in zebrafish embryos and larvae." @default.
• W2790409009 created "2018-03-29" @default.
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• W2790409009 date "2018-06-01" @default.
• W2790409009 modified "2023-10-11" @default.
• W2790409009 title "A protective role of autophagy in TDCIPP-induced developmental neurotoxicity in zebrafish larvae" @default.
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• W2790409009 cites W1755645706 @default.
• W2790409009 cites W1867573724 @default.
• W2790409009 cites W1873294806 @default.
• W2790409009 cites W1969195287 @default.
• W2790409009 cites W1969981762 @default.
• W2790409009 cites W1975692305 @default.
• W2790409009 cites W1978121032 @default.
• W2790409009 cites W1983775513 @default.
• W2790409009 cites W1983940209 @default.
• W2790409009 cites W1985370990 @default.
• W2790409009 cites W1991132159 @default.
• W2790409009 cites W1998294204 @default.
• W2790409009 cites W1999099601 @default.
• W2790409009 cites W2008673871 @default.
• W2790409009 cites W2009816073 @default.
• W2790409009 cites W2013988037 @default.
• W2790409009 cites W2014635574 @default.
• W2790409009 cites W2018079770 @default.
• W2790409009 cites W2025783042 @default.
• W2790409009 cites W2046171022 @default.
• W2790409009 cites W2046982875 @default.
• W2790409009 cites W2050889339 @default.
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• W2790409009 cites W2052827499 @default.
• W2790409009 cites W2053148264 @default.
• W2790409009 cites W2056112729 @default.
• W2790409009 cites W2056663185 @default.
• W2790409009 cites W2058250395 @default.
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• W2790409009 doi "https://doi.org/10.1016/j.aquatox.2018.03.016" @default.
• W2790409009 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29605586" @default.
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