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• W2790419440 abstract "Abstract Objective: This study was conducted to evaluate the treatment effectiveness of Chinese herbal medicine capsules containing the Yangyin Shugan formula (YYSG) in premature ovarian insufficiency (POI). Methods: One-hundred forty-six women with POI participated in this stratified, randomized, double-blind, placebo-controlled clinical trial. Participants in two groups (n = 73 in each)—the YYSG group and control group—underwent treatment for 12 weeks. Outcome measures included the Chinese version Menopause-Specific Quality of Life questionnaire (CMS), serum levels of basal follicle-stimulating hormone (bFSH), basal estradiol, and anti-Mullerian hormone (AMH), the antral follicle count (AFC), and ovarian peak systolic velocity (PSV; cm/s). Results: Treatment with YYSG significantly reduced the total scores of the CMS at the end of the 12th week with statistical significance ( P < 0.01); the vasomotor, psychosocial, physical, and sexual domains significantly improvement after treatment ( P < 0.01). Compared with the baseline hormone levels, YYSG markedly decreased the bFSH level with statistical significance ( P < 0.01) and improved the AMH level ( P < 0.01). Furthermore, YYSG greatly improved the participants’ AFC and ovarian PSV, compared with placebo ( P < 0.01). There were no serious adverse events, and the safety indices of whole blood counts, renal function, and liver function were within the normal range, both before and after treatment. Conclusions: Treatment with YYSG was more effective than placebo for improving menopausal symptoms, basal hormone levels, and ovarian function in women with POI in Guangdong, China." @default.
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• W2790419440 date "2018-08-01" @default.
• W2790419440 modified "2023-10-10" @default.
• W2790419440 title "A randomized, double-blind, placebo-controlled trial of Chinese herbal medicine capsules for the treatment of premature ovarian insufficiency" @default.
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• W2790419440 doi "https://doi.org/10.1097/gme.0000000000001099" @default.
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