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• W2790443345 abstract "Existing ancestral sequence reconstruction techniques are ill-suited to investigating substitutions on a single branch of interest. We present SubRecon, an implementation of a hybrid technique integrating joint and marginal reconstruction for protein sequence data. SubRecon calculates the joint probability of states at adjacent internal nodes in a phylogeny, i.e. how the state has changed along a branch. This does not condition on states at other internal nodes and includes site rate variation. Simulation experiments show the technique to be accurate and powerful. SubRecon has a user-friendly command line interface and produces concise output that is intuitive yet suitable for subsequent parsing in an automated pipeline.SubRecon is platform independent, requiring Java v1.8 or above. Source code, installation instructions and an example dataset are freely available under the Apache 2.0 license at https://github.com/chrismonit/SubRecon." @default.
• W2790443345 created "2018-03-29" @default.
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• W2790443345 date "2018-02-28" @default.
• W2790443345 modified "2023-10-17" @default.
• W2790443345 title "SubRecon: ancestral reconstruction of amino acid substitutions along a branch in a phylogeny" @default.
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• W2790443345 doi "https://doi.org/10.1093/bioinformatics/bty101" @default.
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