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• W2790443375 abstract "<b><i>Background:</i></b> Resveratrol is a natural, nonflavonoid polyphenol, exerting anti-inflammatory activity. It has been reported that resveratrol, together with carboxymethyl-β-glucan, can reduce nasal symptoms in children with allergic rhinitis (AR). In this study, the effect of resveratrol on nasal symptoms in adults with AR was investigated. <b><i>Methods:</i></b> We conducted a placebo-controlled, double-blinded study. One hundred and fifty-one adults (aged 18–60 years) with severe persistent AR were divided into a placebo-treated group (<i>n</i> = 50), a positive control budesonide-treated group (<i>n</i> = 50), and a resveratrol-treated group (<i>n</i> = 51). They were then treated with 2 sprays (100 µL/spray) in each nostril 3 times/day for 1 month. Nasal symptoms including obstruction, itching, sneezing, and rhinorrhea, and the levels of IgE, IL-4, TNF-α, and eosinophils in the blood were assessed at baseline and after treatment. <b><i>Results:</i></b> Adults treated with resveratrol or budesonide achieved a significant reduction in nasal symptoms compared to the placebo-treated group. The resveratrol treatment significantly decreased the IgE, IL-4, TNF-α, and eosinophil levels in the blood. In addition, the resveratrol treatment was found to improve the quality of life of adults with AR. <b><i>Conclusion:</i></b> Our preliminary study showed that intranasal resveratrol is capable of significantly improving nasal symptoms in adults with AR." @default.
• W2790443375 created "2018-03-29" @default.
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• W2790443375 date "2018-01-01" @default.
• W2790443375 modified "2023-09-27" @default.
• W2790443375 title "Preliminary Clinical Effect Evaluation of Resveratrol in Adults with Allergic Rhinitis" @default.
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• W2790443375 doi "https://doi.org/10.1159/000486959" @default.
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