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• W2790455085 abstract "Toxocara canis is the helminth causing Toxocariasis, a parasitic disease with medical and veterinary implications. Their final host are members of the family Canidae and as paratenic hosts, most of the mammals are sensitive (man, rat, mouse, among others). It has been reported that a pituitary hormone, prolactin, it is responsible for reactivation and migration of larvae to the uterus and mammary gland during the last third of gestation in bitches. In addition, this hormone has been shown to play an important role in the regulation of the immune response. Thus, the aim of this study, was to evaluate the effect of hypophysectomy in the rat model of Toxocariasis, on the immune response against this parasite during a chronic infection, for which parasite loads were analyzed in different organs (lung and brain). Furthermore, serum specific antibody titers, and percentages of different cells of the immune system were also determined. The results showed a decrease in the number of larvae recovered from lung and brain in the hypophysectomized animals. In this same group of animals, there was no production of specific antibodies against the parasite. As for the percentages of the cells of the immune system, there are differences in some subpopulations due to surgery and others due to infection. Our results demonstrated that the lack of pituitary hormones alters parasite loads and the immune response to the helminth parasite Toxocara canis." @default.
• W2790455085 created "2018-03-29" @default.
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• W2790455085 date "2018-03-01" @default.
• W2790455085 modified "2023-10-18" @default.
• W2790455085 title "Endocrine immune interactions during chronic Toxocariasis caused by Toxocara canis in a murine model: New insights into the pathophysiology of an old infection" @default.
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• W2790455085 doi "https://doi.org/10.1016/j.vetpar.2018.01.026" @default.
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