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- W2790466592 abstract "The type I interferon pathway has been implicated in the pathogenesis of a number of rheumatic diseases, including systemic lupus erythematosus, Sjögren syndrome, myositis, systemic sclerosis, and rheumatoid arthritis. In normal immune responses, type I interferons have a critical role in the defence against viruses, yet in many rheumatic diseases, large subgroups of patients demonstrate persistent activation of the type I interferon pathway. Genetic variations in type I interferon-related genes are risk factors for some rheumatic diseases, and can explain some of the heterogeneity in type I interferon responses seen between patients within a given disease. Inappropriate activation of the immune response via Toll-like receptors and other nucleic acid sensors also contributes to the dysregulation of the type I interferon pathway in a number of rheumatic diseases. Theoretically, differences in type I interferon activity between patients might predict response to immune-based therapies, as has been demonstrated for rheumatoid arthritis. A number of type I interferon and type I interferon pathway blocking therapies are currently in clinical trials, the results of which are promising thus far. This Review provides an overview of the many ways in which the type I interferon system affects rheumatic diseases." @default.
- W2790466592 created "2018-03-29" @default.
- W2790466592 creator A5069890443 @default.
- W2790466592 creator A5081279169 @default.
- W2790466592 date "2018-03-21" @default.
- W2790466592 modified "2023-10-13" @default.
- W2790466592 title "Type I interferon in rheumatic diseases" @default.
- W2790466592 cites W1479683232 @default.
- W2790466592 cites W1494839184 @default.
- W2790466592 cites W1549764586 @default.
- W2790466592 cites W156829367 @default.
- W2790466592 cites W1594879978 @default.
- W2790466592 cites W1603866561 @default.
- W2790466592 cites W1631384870 @default.
- W2790466592 cites W1639967516 @default.
- W2790466592 cites W1679569810 @default.
- W2790466592 cites W1789511037 @default.
- W2790466592 cites W1848507162 @default.
- W2790466592 cites W1859542580 @default.
- W2790466592 cites W1867181240 @default.
- W2790466592 cites W1870300447 @default.
- W2790466592 cites W1891725391 @default.
- W2790466592 cites W1966579788 @default.
- W2790466592 cites W1968623559 @default.
- W2790466592 cites W1970971642 @default.
- W2790466592 cites W1971833707 @default.
- W2790466592 cites W1976373964 @default.
- W2790466592 cites W1977054607 @default.
- W2790466592 cites W1978231377 @default.
- W2790466592 cites W1979037559 @default.
- W2790466592 cites W1982983059 @default.
- W2790466592 cites W1986628830 @default.
- W2790466592 cites W1993095369 @default.
- W2790466592 cites W1995744610 @default.
- W2790466592 cites W1997069349 @default.
- W2790466592 cites W1997125513 @default.
- W2790466592 cites W1998217022 @default.
- W2790466592 cites W2000177767 @default.
- W2790466592 cites W2005375258 @default.
- W2790466592 cites W2007719563 @default.
- W2790466592 cites W2008423777 @default.
- W2790466592 cites W2010160850 @default.
- W2790466592 cites W2011330612 @default.
- W2790466592 cites W2012127574 @default.
- W2790466592 cites W2012962041 @default.
- W2790466592 cites W2014008318 @default.
- W2790466592 cites W2015121619 @default.
- W2790466592 cites W2015208411 @default.
- W2790466592 cites W2015310325 @default.
- W2790466592 cites W2016447788 @default.
- W2790466592 cites W2017831613 @default.
- W2790466592 cites W2017888326 @default.
- W2790466592 cites W2019740286 @default.
- W2790466592 cites W2019965289 @default.
- W2790466592 cites W2019992165 @default.
- W2790466592 cites W2021109112 @default.
- W2790466592 cites W2021268151 @default.
- W2790466592 cites W2026255377 @default.
- W2790466592 cites W2028825739 @default.
- W2790466592 cites W2034523427 @default.
- W2790466592 cites W2034915145 @default.
- W2790466592 cites W2035242178 @default.
- W2790466592 cites W2035718151 @default.
- W2790466592 cites W2036095604 @default.
- W2790466592 cites W2038139581 @default.
- W2790466592 cites W2039767493 @default.
- W2790466592 cites W2042751933 @default.
- W2790466592 cites W2043618452 @default.
- W2790466592 cites W2043959346 @default.
- W2790466592 cites W2048246423 @default.
- W2790466592 cites W2048333225 @default.
- W2790466592 cites W2049283993 @default.
- W2790466592 cites W2053248858 @default.
- W2790466592 cites W2054355572 @default.
- W2790466592 cites W2057102103 @default.
- W2790466592 cites W2060351820 @default.
- W2790466592 cites W2060926084 @default.
- W2790466592 cites W2061173833 @default.
- W2790466592 cites W2061471228 @default.
- W2790466592 cites W2061819326 @default.
- W2790466592 cites W2062162039 @default.
- W2790466592 cites W2062713016 @default.
- W2790466592 cites W2068197701 @default.
- W2790466592 cites W2071670416 @default.
- W2790466592 cites W2072127157 @default.
- W2790466592 cites W2076690763 @default.
- W2790466592 cites W2076831973 @default.
- W2790466592 cites W2080549619 @default.
- W2790466592 cites W2081363673 @default.
- W2790466592 cites W2081761456 @default.
- W2790466592 cites W2084676421 @default.
- W2790466592 cites W2085013699 @default.
- W2790466592 cites W2085237060 @default.
- W2790466592 cites W2088052489 @default.
- W2790466592 cites W2088722807 @default.
- W2790466592 cites W2089833447 @default.
- W2790466592 cites W2091018161 @default.
- W2790466592 cites W2092198587 @default.