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- W2790481421 abstract "Abstract Diabetic cardiomyopathy is a distinct pathology characterized by early emergence of diastolic dysfunction. Increased cardiovascular risk associated with diabetes is more marked for women, but an understanding of the role of diastolic dysfunction in female susceptibility to diabetic cardiomyopathy is lacking. To investigate the sex-specific relationship between systemic diabetic status and in vivo occurrence of diastolic dysfunction, diabetes was induced in male and female mice by streptozotocin (5x daily i.p. 55 mg/kg). Echocardiography was performed at 7 weeks post-diabetes induction, cardiac collagen content assessed by picrosirius red staining, and gene expression measured using qPCR. The extent of diabetes-associated hyperglycemia was more marked in males than females (males: 25.8 ± 1.2 vs 9.1 ± 0.4 mM; females: 13.5 ± 1.5 vs 8.4 ± 0.4 mM, p < 0.05) yet in vivo diastolic dysfunction was evident in female (E/E′ 54% increase, p < 0.05) but not male diabetic mice. Cardiac structural abnormalities (left ventricular wall thinning, collagen deposition) were similar in male and female diabetic mice. Female-specific gene expression changes in glucose metabolic and autophagy-related genes were evident. This study demonstrates that STZ-induced diabetic female mice exhibit a heightened susceptibility to diastolic dysfunction, despite exhibiting a lower extent of hyperglycemia than male mice. These findings highlight the importance of early echocardiographic screening of asymptomatic prediabetic at-risk patients." @default.
- W2790481421 created "2018-03-29" @default.
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- W2790481421 date "2018-02-05" @default.
- W2790481421 modified "2023-10-18" @default.
- W2790481421 title "Diastolic dysfunction is more apparent in STZ-induced diabetic female mice, despite less pronounced hyperglycemia" @default.
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- W2790481421 cites W1979135798 @default.
- W2790481421 cites W1981077468 @default.
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- W2790481421 cites W1991831303 @default.
- W2790481421 cites W1993947592 @default.
- W2790481421 cites W1997385830 @default.
- W2790481421 cites W2003665146 @default.
- W2790481421 cites W2006499762 @default.
- W2790481421 cites W2009490879 @default.
- W2790481421 cites W2014939221 @default.
- W2790481421 cites W2015552976 @default.
- W2790481421 cites W2018559323 @default.
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- W2790481421 cites W2077773186 @default.
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- W2790481421 doi "https://doi.org/10.1038/s41598-018-20703-8" @default.
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