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- W2790485737 endingPage "330" @default.
- W2790485737 startingPage "319" @default.
- W2790485737 abstract "Selective serotonin reuptake inhibitors (SSRIs) are the most effective and most used antidepressant drugs. Acting by inhibiting serotonin (5-HT) transporter, SSRIs display a typical 3-4-week delay in their therapeutic effects, with nearly 40% of depressed patients remaining treatment-resistant. Recent evidence suggests complex interplay between 5-HT receptors and key proteins of 5-HT metabolism in molecular mechanisms of such delay and resistance to SSRIs. Area covered: This paper concentrates on the interplay between 5-HT receptors in the delay of therapeutic effect of SSRIs, and the interaction between tryptophan hydroxylase 2 and 5-HT transporter in the SSRI resistance. Specifically, it discusses: (1) the data on the association between antidepressant drug efficacy and genetically defined characteristics of key proteins in the 5-HT signaling (TPH2, MAOA, SERT and 5-HT1A receptor), (2) the effect of dimerization of 5-HT7 and 5-HT1A receptors on the internalization and functioning of 5-HT1A presynaptic receptors, (3) the role of Tph2 deficiency in the resistance to SSRIs treatment. We shift the emphasis from individual proteins to their interactions in explaining antidepressant action of SSRI. Expert opinion: These interactions should be considered when developing more effective antidepressant drugs as well as for predicting and improving the efficacy of antidepressant therapies." @default.
- W2790485737 created "2018-03-29" @default.
- W2790485737 creator A5001115050 @default.
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- W2790485737 creator A5016370068 @default.
- W2790485737 creator A5055255949 @default.
- W2790485737 creator A5069347743 @default.
- W2790485737 date "2018-04-03" @default.
- W2790485737 modified "2023-09-24" @default.
- W2790485737 title "Interplay between the key proteins of serotonin system in SSRI antidepressants efficacy" @default.
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