Matches in SemOpenAlex for { <https://semopenalex.org/work/W2790492473> ?p ?o ?g. }
- W2790492473 endingPage "133" @default.
- W2790492473 startingPage "117" @default.
- W2790492473 abstract "This chapter focuses on the enzymes and mechanisms involved in lagging-strand DNA replication in eukaryotic cells. Recent structural and biochemical progress with DNA polymerase α-primase (Pol α) provides insights how each of the millions of Okazaki fragments in a mammalian cell is primed by the primase subunit and further extended by its polymerase subunit. Rapid kinetic studies of Okazaki fragment elongation by Pol δ illuminate events when the polymerase encounters the double-stranded RNA-DNA block of the preceding Okazaki fragment. This block acts as a progressive molecular break that provides both time and opportunity for the flap endonuclease 1 (FEN1) to access the nascent flap and cut it. The iterative action of Pol δ and FEN1 is coordinated by the replication clamp PCNA and produces a regulated degradation of the RNA primer, thereby preventing the formation of long-strand displacement flaps. Occasional long flaps are further processed by backup nucleases including Dna2." @default.
- W2790492473 created "2018-03-29" @default.
- W2790492473 creator A5054552035 @default.
- W2790492473 creator A5071638186 @default.
- W2790492473 date "2017-01-01" @default.
- W2790492473 modified "2023-09-26" @default.
- W2790492473 title "Mechanism of Lagging-Strand DNA Replication in Eukaryotes" @default.
- W2790492473 cites W154360567 @default.
- W2790492473 cites W1552229310 @default.
- W2790492473 cites W1579409894 @default.
- W2790492473 cites W1587132435 @default.
- W2790492473 cites W1607976858 @default.
- W2790492473 cites W1625430625 @default.
- W2790492473 cites W1640638881 @default.
- W2790492473 cites W1754682352 @default.
- W2790492473 cites W1772122236 @default.
- W2790492473 cites W1774053018 @default.
- W2790492473 cites W1966219094 @default.
- W2790492473 cites W1966666560 @default.
- W2790492473 cites W1968760263 @default.
- W2790492473 cites W1970184264 @default.
- W2790492473 cites W1972746487 @default.
- W2790492473 cites W1973440927 @default.
- W2790492473 cites W1973535211 @default.
- W2790492473 cites W1973773596 @default.
- W2790492473 cites W1980178566 @default.
- W2790492473 cites W1980781636 @default.
- W2790492473 cites W1984518551 @default.
- W2790492473 cites W1986084992 @default.
- W2790492473 cites W1989388273 @default.
- W2790492473 cites W1989821243 @default.
- W2790492473 cites W1992391204 @default.
- W2790492473 cites W1995073945 @default.
- W2790492473 cites W1997002747 @default.
- W2790492473 cites W1998495506 @default.
- W2790492473 cites W1999593568 @default.
- W2790492473 cites W2001031455 @default.
- W2790492473 cites W2001731565 @default.
- W2790492473 cites W2010302368 @default.
- W2790492473 cites W2013899585 @default.
- W2790492473 cites W2014523793 @default.
- W2790492473 cites W2016218438 @default.
- W2790492473 cites W2018644522 @default.
- W2790492473 cites W2025064120 @default.
- W2790492473 cites W2029632391 @default.
- W2790492473 cites W2034535098 @default.
- W2790492473 cites W2038350526 @default.
- W2790492473 cites W2038529419 @default.
- W2790492473 cites W2046261037 @default.
- W2790492473 cites W2051555627 @default.
- W2790492473 cites W2051824863 @default.
- W2790492473 cites W2052079265 @default.
- W2790492473 cites W2053213954 @default.
- W2790492473 cites W2054693978 @default.
- W2790492473 cites W2057281180 @default.
- W2790492473 cites W2059184834 @default.
- W2790492473 cites W2059724871 @default.
- W2790492473 cites W2063771471 @default.
- W2790492473 cites W2064743913 @default.
- W2790492473 cites W2066261076 @default.
- W2790492473 cites W2069352564 @default.
- W2790492473 cites W2074050403 @default.
- W2790492473 cites W2076046893 @default.
- W2790492473 cites W2082175154 @default.
- W2790492473 cites W2082749639 @default.
- W2790492473 cites W2086103125 @default.
- W2790492473 cites W2086219095 @default.
- W2790492473 cites W2089594949 @default.
- W2790492473 cites W2095206600 @default.
- W2790492473 cites W2095769358 @default.
- W2790492473 cites W2096781614 @default.
- W2790492473 cites W2100310707 @default.
- W2790492473 cites W2104261681 @default.
- W2790492473 cites W2107856790 @default.
- W2790492473 cites W2109509010 @default.
- W2790492473 cites W2109952859 @default.
- W2790492473 cites W2111313204 @default.
- W2790492473 cites W2120628590 @default.
- W2790492473 cites W2123218200 @default.
- W2790492473 cites W2125915154 @default.
- W2790492473 cites W2129849452 @default.
- W2790492473 cites W2132386714 @default.
- W2790492473 cites W2133143725 @default.
- W2790492473 cites W2133231925 @default.
- W2790492473 cites W2137278429 @default.
- W2790492473 cites W2138055292 @default.
- W2790492473 cites W2140384792 @default.
- W2790492473 cites W2142596193 @default.
- W2790492473 cites W2144128376 @default.
- W2790492473 cites W2146851796 @default.
- W2790492473 cites W2153314555 @default.
- W2790492473 cites W2158881007 @default.
- W2790492473 cites W2159127144 @default.
- W2790492473 cites W2160735284 @default.
- W2790492473 cites W2161248815 @default.
- W2790492473 cites W2165926703 @default.
- W2790492473 cites W2166150079 @default.
- W2790492473 cites W2166672594 @default.