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- W2790492706 abstract "The study of Hodgkin lymphoma (HL), with its unique microenvironment and long-term follow-up, has provided exceptional insights into several areas of tumor biology. Findings in HL have not only improved our understanding of human carcinogenesis, but have also pioneered its translation into the clinics. HL is a successful paradigm of modern treatment strategies. Nonetheless, approximately 15–20% of patients with advanced stage HL still die following relapse or progressive disease and a similar proportion of patients are over-treated, leading to treatment-related late sequelae, including solid tumors and organ dysfunction. The malignant cells in HL are characterized by a highly altered genomic landscape with a wide spectrum of genomic alterations, including somatic mutations, copy number alterations, complex chromosomal rearrangements, and aneuploidy. Here, we review the chromosomal instability mechanisms in HL, starting with the cellular origin of neoplastic cells and the mechanisms supporting HL pathogenesis, focusing particularly on the role of the microenvironment, including the influence of viruses and macrophages on the induction of chromosomal instability in HL. We discuss the emerging possibilities to exploit these aberrations as prognostic biomarkers and guides for personalized patient management." @default.
- W2790492706 created "2018-03-29" @default.
- W2790492706 creator A5029627993 @default.
- W2790492706 creator A5030282953 @default.
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- W2790492706 creator A5068572026 @default.
- W2790492706 creator A5070508738 @default.
- W2790492706 creator A5083914679 @default.
- W2790492706 date "2018-03-26" @default.
- W2790492706 modified "2023-09-26" @default.
- W2790492706 title "Chromosomal Instability in Hodgkin Lymphoma: An In-Depth Review and Perspectives" @default.
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