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- W2790512958 abstract "Complement component 3 (C3) plays a central role in the complement system whose activation is essential for all the important functions performed by this system. Here, a novel C3 gene, termed Mc-C3, was identified from thick shell mussel (Mytilus coruscus). The deduced Mc-C3 protein possessed the characteristic structure features present in its homologs and contained the A2M_N_2, ANATO, A2M, A2M_comp, A2M_recep, and C345C domains, as well as the C3 convertase cleavage site, thioester motif, and conserved Cys, His, and Glu residues. Mc-C3 gene constitutively expressed in all examined tissues and predominantly expressed in immune-related tissues such as gills, hemocytes and hepatopancreas. After stimulation with lipopolysaccharide or Cu2+, the expression of Mc-C3 was significantly induced in gills. Further luciferase reporter assays showed the ability for activation of NF-κB signaling transduction of Mc-C3a. Taken together, these results show that C3 may play an essential role in the immune defense of M. coruscus. The present data therefore provide a more detailed insight into the functional activities of the bivalve complement system." @default.
- W2790512958 created "2018-03-29" @default.
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- W2790512958 date "2018-05-01" @default.
- W2790512958 modified "2023-10-16" @default.
- W2790512958 title "Molecular characterization of complement component 3 (C3) in Mytilus coruscus improves our understanding of bivalve complement system" @default.
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- W2790512958 doi "https://doi.org/10.1016/j.fsi.2018.02.044" @default.
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