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• W2790520041 abstract "Unlike reported bisindoles linked by single bond directly, alstoniasidines A (1) and B (2), from Alstonia scholaris featuring unprecedented skeleton with two indole moieties bridged by a sugar, represented a novel bisindole type having strictosamide-glucopyranose-picraline scaffold. Both compounds exhibited selective cytotoxicity against human glioma stem cells (GSCs) and induced caspase-3 dependent extrinsic apoptosis by increasing the expression of interleukin 1 (IL-1), tumor necrosis factor (TNF-α), and the cleaved caspase-3, while damaged the unlimited proliferation and self-renewal capacity of GSCs. This finding might provide new type of leads for the selective killing of human glioma stem cells." @default.
• W2790520041 created "2018-03-29" @default.
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• W2790520041 date "2018-05-01" @default.
• W2790520041 modified "2023-10-14" @default.
• W2790520041 title "Unprecedented sugar bridged bisindoles selective inhibiting glioma stem cells" @default.
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• W2790520041 doi "https://doi.org/10.1016/j.bmc.2018.02.024" @default.
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