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• W2790538367 startingPage "53" @default.
• W2790538367 abstract "Tick saliva is critically important for continuous attachment to the host, blood feeding for days, and transmission of tick-borne pathogens. To characterize the patterns of inflammatory cytokine gene expression during its attachment and blood sucking time, peripheral blood samples of rabbits infested with Haemaphysalis longicornis ticks were collected at different intervals. Blood histamine concentration was evaluated as well as gene encoding IFN-γ, TNF-α, IL-2, IL-6, IL-4, and IL-10 were compared with non-infested rabbits. Blood histamine concentration of tick-infested rabbits during fast feeding time was significantly higher than that of non-infested rabbits. In both nymph and adult tick infested rabbits, expression of TNF-α and IFN-γ genes were decreased significantly (P<0.05), while expression of IL-4, IL-6, and IL-10 were increased 1.3 to 7 folds in adult infested rabbits with the exception of IL-6 that was significantly (P<0.05) decreased in nymph infested rabbits. IL-2 was not expressed in either nymph or adult infestation. H. longicornis saliva is capable of modulate host responses through a complex correlation with histamine and Th1, Th2 mediated cytokines that suppress the inflammatory responses directed toward inflammatory mediators introduced into the host during tick feeding." @default.
• W2790538367 created "2018-03-29" @default.
• W2790538367 creator A5051071065 @default.
• W2790538367 creator A5076244808 @default.
• W2790538367 date "2018-02-28" @default.
• W2790538367 modified "2023-09-25" @default.
• W2790538367 title "Expression Patterns of Host Inflammatory Cytokine Genes during Infestation with Haemaphysalis longicornis, a Zoonotic Vector, in Blood Sucking Periods" @default.
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• W2790538367 doi "https://doi.org/10.3347/kjp.2018.56.1.53" @default.
• W2790538367 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5858668" @default.
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• W2790538367 hasPublicationYear "2018" @default.
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