FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2790583061> ?p ?o ?g. }

• W2790583061 endingPage "H32" @default.
• W2790583061 startingPage "H18" @default.
• W2790583061 abstract "Increased vascular stiffness correlates with a higher risk of cardiovascular complications in aging adults. Elastin (ELN) insufficiency, as observed in patients with Williams-Beuren syndrome or with familial supravalvular aortic stenosis, also increases vascular stiffness and leads to arterial narrowing. We used Eln +/− mice to test the hypothesis that pathologically increased vascular stiffness with concomitant arterial narrowing leads to decreased blood flow to end organs such as the brain. We also hypothesized that drugs that remodel arteries and increase lumen diameter would improve flow. To test these hypotheses, we compared carotid blood flow using ultrasound and cerebral blood flow using MRI-based arterial spin labeling in wild-type (WT) and Eln +/− mice. We then studied how minoxidil, an ATP-sensitive K + channel opener and vasodilator, affects vessel mechanics, blood flow, and gene expression. Both carotid and cerebral blood flows were lower in Eln +/− mice than in WT mice. Treatment of Eln +/− mice with minoxidil lowered blood pressure and reduced functional arterial stiffness to WT levels. Minoxidil also improved arterial diameter and restored carotid and cerebral blood flows in Eln +/− mice. The beneficial effects persisted for weeks after drug removal. RNA-Seq analysis revealed differential expression of 127 extracellular matrix-related genes among the treatment groups. These results indicate that ELN insufficiency impairs end-organ perfusion, which may contribute to the increased cardiovascular risk. Minoxidil, despite lowering blood pressure, improves end-organ perfusion. Changes in matrix gene expression and persistence of treatment effects after drug withdrawal suggest arterial remodeling. Such remodeling may benefit patients with genetic or age-dependent ELN insufficiency. NEW & NOTEWORTHY Our work with a model of chronic vascular stiffness, the elastin ( Eln) +/− mouse, shows reduced brain perfusion as measured by carotid ultrasound and MRI arterial spin labeling. Vessel caliber, functional stiffness, and blood flow improved with minoxidil. The ATP-sensitive K + channel opener increased Eln gene expression and altered 126 other matrix-associated genes." @default.
• W2790583061 created "2018-03-29" @default.
• W2790583061 creator A5003759318 @default.
• W2790583061 creator A5005631326 @default.
• W2790583061 creator A5007118272 @default.
• W2790583061 creator A5010527590 @default.
• W2790583061 creator A5013973657 @default.
• W2790583061 creator A5016948672 @default.
• W2790583061 creator A5023087890 @default.
• W2790583061 creator A5025055562 @default.
• W2790583061 creator A5047810681 @default.
• W2790583061 creator A5052008214 @default.
• W2790583061 creator A5061969474 @default.
• W2790583061 creator A5062215131 @default.
• W2790583061 creator A5077021350 @default.
• W2790583061 creator A5080025502 @default.
• W2790583061 date "2018-07-01" @default.
• W2790583061 modified "2023-10-13" @default.
• W2790583061 title "Minoxidil improves vascular compliance, restores cerebral blood flow, and alters extracellular matrix gene expression in a model of chronic vascular stiffness" @default.
• W2790583061 cites W1653019055 @default.
• W2790583061 cites W1964546363 @default.
• W2790583061 cites W1966930409 @default.
• W2790583061 cites W1971569271 @default.
• W2790583061 cites W1976099054 @default.
• W2790583061 cites W1986715377 @default.
• W2790583061 cites W1989149550 @default.
• W2790583061 cites W1990065094 @default.
• W2790583061 cites W1996498530 @default.
• W2790583061 cites W1998040719 @default.
• W2790583061 cites W1999382996 @default.
• W2790583061 cites W2009333744 @default.
• W2790583061 cites W2015996457 @default.
• W2790583061 cites W2017725919 @default.
• W2790583061 cites W2021496866 @default.
• W2790583061 cites W2024264687 @default.
• W2790583061 cites W2028507273 @default.
• W2790583061 cites W205201254 @default.
• W2790583061 cites W2058670868 @default.
• W2790583061 cites W2061716485 @default.
• W2790583061 cites W2062747021 @default.
• W2790583061 cites W2064058462 @default.
• W2790583061 cites W2068848069 @default.
• W2790583061 cites W2071767826 @default.
• W2790583061 cites W2073431571 @default.
• W2790583061 cites W2094550322 @default.
• W2790583061 cites W2099101745 @default.
• W2790583061 cites W2099609467 @default.
• W2790583061 cites W2102141373 @default.
• W2790583061 cites W2103439453 @default.
• W2790583061 cites W2114833286 @default.
• W2790583061 cites W2117768135 @default.
• W2790583061 cites W2118522871 @default.
• W2790583061 cites W2121679604 @default.
• W2790583061 cites W2126281524 @default.
• W2790583061 cites W2127942290 @default.
• W2790583061 cites W2129508557 @default.
• W2790583061 cites W2130331710 @default.
• W2790583061 cites W2130896405 @default.
• W2790583061 cites W2138207763 @default.
• W2790583061 cites W2142207652 @default.
• W2790583061 cites W2143286808 @default.
• W2790583061 cites W2150156315 @default.
• W2790583061 cites W2151779288 @default.
• W2790583061 cites W2159957894 @default.
• W2790583061 cites W2169456326 @default.
• W2790583061 cites W2171591131 @default.
• W2790583061 cites W2179438025 @default.
• W2790583061 cites W2313524789 @default.
• W2790583061 cites W2316615891 @default.
• W2790583061 cites W2324223719 @default.
• W2790583061 cites W2338608341 @default.
• W2790583061 cites W2415620348 @default.
• W2790583061 cites W2463802074 @default.
• W2790583061 cites W2476542314 @default.
• W2790583061 cites W2527609605 @default.
• W2790583061 cites W2569159849 @default.
• W2790583061 cites W4245569264 @default.
• W2790583061 cites W797317773 @default.
• W2790583061 doi "https://doi.org/10.1152/ajpheart.00683.2017" @default.
• W2790583061 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6087770" @default.
• W2790583061 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29498532" @default.
• W2790583061 hasPublicationYear "2018" @default.
• W2790583061 type Work @default.
• W2790583061 sameAs 2790583061 @default.
• W2790583061 citedByCount "40" @default.
• W2790583061 countsByYear W27905830612018 @default.
• W2790583061 countsByYear W27905830612019 @default.
• W2790583061 countsByYear W27905830612020 @default.
• W2790583061 countsByYear W27905830612021 @default.
• W2790583061 countsByYear W27905830612022 @default.
• W2790583061 countsByYear W27905830612023 @default.
• W2790583061 crossrefType "journal-article" @default.
• W2790583061 hasAuthorship W2790583061A5003759318 @default.
• W2790583061 hasAuthorship W2790583061A5005631326 @default.
• W2790583061 hasAuthorship W2790583061A5007118272 @default.
• W2790583061 hasAuthorship W2790583061A5010527590 @default.
• W2790583061 hasAuthorship W2790583061A5013973657 @default.
• W2790583061 hasAuthorship W2790583061A5016948672 @default.

• next